Evidence map›Paper›PMID 27822465›Full record

ArticleFrontiers in public health2016

Additive Interaction between Heterogeneous Environmental Quality Domains (Air, Water, Land, Sociodemographic, and Built Environment) on Preterm Birth.

Shannon C Grabich, Kristen M Rappazzo, Christine L Gray, Jyotsna S Jagai, Yun Jian, Lynne C Messer, Danelle T Lobdell

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in public health, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Environmental Quality and Invasive Breast Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shannon C GrabichNational Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park , Chapel Hill, NC , USA.
Kristen M RappazzoNational Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park , Chapel Hill, NC , USA.
Christine L GrayNational Health and Environmental Effects Research Laboratory, Oak Ridge Institute for Science and Education, U.S. Environmental Protection Agency, Chapel Hill, NC, USA; Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
Jyotsna S JagaiDivision of Environmental and Occupational Health Sciences, School of Public Health, University of Illinois Chicago , Chicago, IL , USA.
Yun JianNational Health and Environmental Effects Research Laboratory, Oak Ridge Institute for Science and Education, U.S. Environmental Protection Agency , Chapel Hill, NC , USA.
Lynne C MesserSchool of Community Health, College of Urban and Public Affairs, Portland State University , Portland, OR , USA.
Danelle T LobdellNational Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park , Chapel Hill, NC , USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEnvironmental exposures often occur in tandem; however, epidemiological research often focuses on singular exposures. Statistical interactions among broad, well-characterized environmental domains have not yet been evaluated in association with health. We address this gap by conducting a county-level cross-sectional analysis of interactions between Environmental Quality Index (EQI) domain indices on preterm birth in the Unites States from 2000 to 2005.

methodsThe EQI, a county-level index constructed for the 2000-2005 time period, was constructed from five domain-specific indices (air, water, land, built, and sociodemographic) using principal component analyses. County-level preterm birth rates (

resultsWe found the suggestion of antagonistic interactions but no synergism, along with several purely additive (i.e., no interaction) associations. In the non-stratified model, we observed antagonistic interactions, between the sociodemographic/air domains [net effect (i.e., the association, including main effects and interaction effects) PD: -0.004 (95% CI: -0.007, 0.000), interaction contrast: -0.013 (95% CI: -0.020, -0.007)] and built/air domains [net effect PD: 0.008 (95% CI 0.004, 0.011), interaction contrast: -0.008 (95% CI: -0.015, -0.002)]. Most interactions were between the air domain and other respective domains. Interactions differed by urbanicity, with more interactions observed in non-metropolitan regions.

conclusionObserved antagonistic associations may indicate that those living in areas with multiple detrimental domains may have other interfering factors reducing the burden of environmental exposure. This study is the first to explore interactions across different environmental domains and demonstrates the utility of the EQI to examine the relationship between environmental domain interactions and human health. While we did observe some departures from additivity, many observed effects were additive. This study demonstrated that interactions between environmental domains should be considered in future analyses.

Indexed as

airbuilt environmentenvironmental qualityinteractionlandpreterm birthsociodemographicwater

Identifiers

PMID27822465
PMCPMC5076290

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.