Evidence map›Paper›PMID 27822335›Full record

ArticleThe journal of physical chemistry. C, Nanomaterials and interfaces2016

Electrostatic Interactions and Protein Competition Reveal a Dynamic Surface in Gold Nanoparticle-Protein Adsorption.

Ailin Wang, Y Randika Perera, Mackenzie B Davidson, Nicholas C Fitzkee

Abstract read
In one paragraph

Article in The journal of physical chemistry. C, Nanomaterials and interfaces, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ailin WangDepartment of Chemistry, Mississippi State University, Mississippi State, Mississippi 39762, United States.
Y Randika PereraDepartment of Chemistry, Mississippi State University, Mississippi State, Mississippi 39762, United States.
Mackenzie B DavidsonDepartment of Chemistry, Mississippi State University, Mississippi State, Mississippi 39762, United States.
Nicholas C FitzkeeDepartment of Chemistry, Mississippi State University, Mississippi State, Mississippi 39762, United States.

Funding

Functionalized Gold Nanoparticles: Understanding the Mechanism of Protein BindingR15GM113152 · NIGMS · MISSISSIPPI STATE UNIVERSITY · PI FITZKEE, NICHOLAS C · 2015 to 2015
$339k
NIGMS NIH HHS R15 GM113152
6 · The paper itself

Abstract

Gold nanoparticle- (AuNP-) protein conjugates are potentially useful in a broad array of diagnostic and therapeutic applications, but the physical basis of the simultaneous adsorption of multiple proteins onto AuNP surfaces remains poorly understood. Here, we investigate the contribution of electrostatic interactions to protein-AuNP binding by studying the pH-dependent binding behavior of two proteins, GB3 and ubiquitin. For both proteins, binding to 15-nm citrate-coated AuNPs closely tracks with the predicted net charge using standard p

Identifiers

PMID27822335
PMCPMC5096844

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.