Evidence map›Paper›PMID 27822202›Full record

ArticleFrontiers in microbiology2016

Absence of Protoheme IX Farnesyltransferase CtaB Causes Virulence Attenuation but Enhances Pigment Production and Persister Survival in MRSA.

Tao Xu, Jian Han, Jia Zhang, Jiazhen Chen, Nan Wu, Wenhong Zhang, Ying Zhang

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
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  6. Bacterial persisters: molecular mechanisms and therapeutic development.Signal transduction and targeted therapy · 2024
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  7. PurN Is Involved in Antibiotic Tolerance and Virulence inAntibiotics (Basel, Switzerland) · 2022
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Influence of ISAntimicrobial agents and chemotherapy · 2017
    Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Tao XuKey Laboratory of Medical Molecular Virology, Huashan Hospital, Shanghai Medical College of Fudan University Shanghai, China.
Jian HanDepartment of Pathogenic Biology, School of Basic Medical Sciences, Lanzhou University Lanzhou, China.
Jia ZhangKey Laboratory of Medical Molecular Virology, Huashan Hospital, Shanghai Medical College of Fudan University Shanghai, China.
Jiazhen ChenKey Laboratory of Medical Molecular Virology, Huashan Hospital, Shanghai Medical College of Fudan University Shanghai, China.
Nan WuKey Laboratory of Medical Molecular Virology, Huashan Hospital, Shanghai Medical College of Fudan University Shanghai, China.
Wenhong ZhangKey Laboratory of Medical Molecular Virology, Huashan Hospital, Shanghai Medical College of Fudan University Shanghai, China.
Ying ZhangKey Laboratory of Medical Molecular Virology, Huashan Hospital, Shanghai Medical College of Fudan UniversityShanghai, China; Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins UniversityBaltimore, MD, USA.
Huashan Hospital · CNShanghai Medical College of Fudan University · CNJohns Hopkins University · USLanzhou University · CN

Funding

Pyrazinamide and Trans-Translation in Mycobacterium tuberculosisR01AI099512 · NIAID · JOHNS HOPKINS UNIVERSITY · PI ZHANG, YING · 2012 to 2015
$1.7M
Toxin-antitoxins & RpsA in TB drug resistance & persistence with HIVR21AI108535 · NIAID · JOHNS HOPKINS UNIVERSITY · PI ZHANG, YING · 2014 to 2015
$443k
NIAID NIH HHS R01 AI099512NIAID NIH HHS R21 AI108535
6 · The paper itself

Abstract

The membrane protein CtaB in

Indexed as

antibioticshemepersister formationpigmentStaphylococcus aureusvirulence

Identifiers

PMID27822202
PMCPMC5076432
OpenAlexW2535464770

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.