ArticleFrontiers in neurology2016
Immediate and Longitudinal Alterations of Functional Networks after Thalamotomy in Essential Tremor.
Article in Frontiers in neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Imaging the Pathophysiology of Essential Tremor-A Systematic Review.Frontiers in neurology · 2021Pooled it
- Functional network reorganization after magnetic resonance-guided focused ultrasound thalamotomy in tremor-dominant Parkinson's disease patients.NeuroImage. Clinical · 2026Article
- Functional network reorganization following VIM-MRgFUS for essential tremor.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Article
- The Results of a 12-Month Open-Label Follow-Up Study with MRI Monitoring of Patients with Parkinson's Disease After MRI-Guided FUS.Journal of clinical medicine · 2025Article
- Volumetric Assessment and Graph Theoretical Analysis of Thalamic Nuclei in Essential Tremor.Brain and behavior · 2025Article
- MR-guided focused ultrasound thalamotomy modulates cerebello-thalamo-cortical tremor network in essential tremor patients.Frontiers in neurology · 2025Article
- Quantitative Tractography-Based Evaluations in Essential Tremor Patients after MRgFUS Thalamotomy.Movement disorders clinical practice · 2024Article
- Differential patterns of functional connectivity in tremor dominant Parkinson's disease and essential tremor plus.Journal of neural transmission (Vienna, Austria : 1996) · 2024Article
- Cognitive safety of focused ultrasound thalamotomy for tremor: 1-year follow-up results of the COGNIFUS part 2 study.Frontiers in neurology · 2024Article
- Magnetic Resonance-Guided Focused Ultrasound Thalamotomy Rebalances Atypical Functional Hierarchy in Patients with Essential Tremor.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Article
- Changes in the Cerebello-Thalamo-Cortical Network After Magnetic Resonance-Guided Focused Ultrasound Thalamotomy.Brain connectivity · 2023Article
- The variation of functional connectivity and activity before and after thalamotomy surgery (review).Frontiers in human neuroscience · 2023Review
- Morphometric features of drug-resistant essential tremor and recovery after stereotactic radiosurgical thalamotomy.Network neuroscience (Cambridge, Mass.) · 2022Article
- Graph Theoretical Analysis of Structural Covariance Reveals the Relevance of Visuospatial and Attentional Areas in Essential Tremor Recovery After Stereotactic Radiosurgical Thalamotomy.Frontiers in aging neuroscience · 2022Article
- Combined brain network topological metrics with machine learning algorithms to identify essential tremor.Frontiers in neuroscience · 2022Article
- Disrupted Brain Network Topology in Drug-naïve Essential Tremor Patients with and Without Depression : A Resting State Functional Magnetic Resonance Imaging Study.Clinical neuroradiology · 2021Article
- Bayesian estimation of maximum entropy model for individualized energy landscape analysis of brain state dynamics.Human brain mapping · 2021Article
- Altered spontaneous brain activity in essential tremor with and without resting tremor: a resting-state fMRI study.Magma (New York, N.Y.) · 2021Article
- Resting State Functional Connectivity Signatures of MRgFUS Vim Thalamotomy in Parkinson's Disease: A Preliminary Study.Frontiers in neurology · 2021Article
- Cerebello-thalamo-cortical network is intrinsically altered in essential tremor: evidence from a resting state functional MRI study.Scientific reports · 2020Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thalamotomy at the ventralis intermedius nucleus has been an effective treatment method for essential tremor, but how the brain network changes immediately responding to this deliberate lesion and then reorganizes afterwards are not clear. Taking advantage of a non-cranium-opening MRI-guided focused ultrasound ablation technique, we investigated functional network changes due to a focal lesion. To classify the diverse time courses of those network changes with respect to symptom-related long-lasting treatment effects and symptom-unrelated transient effects, we applied graph-theoretic analyses to longitudinal resting-state functional magnetic resonance imaging data before and 1 day, 7 days, and 3 months after thalamotomy with essential tremor. We found reduced average connections among the motor-related areas, reduced connectivity between substantia nigra and external globus pallidum and reduced total connection in the thalamus after thalamotomy, which are all associated with clinical rating scales. The average connectivity among whole brain regions and inter-hemispheric network asymmetry show symptom-unrelated transient increases, indicating temporary reconfiguration of the whole brain network. In summary, thalamotomy regulates interactions over the motor network via symptom-related connectivity changes but accompanies transient, symptom-unrelated diaschisis in the global brain network. This study suggests the significance of longitudinal network analysis, combined with minimal-invasive treatment techniques, in understanding time-dependent diaschisis in the brain network due to a focal lesion.
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