ArticleFrontiers in pharmacology2016
A Snapshot on the On-Label and Off-Label Use of the Interleukin-1 Inhibitors in Italy among Rheumatologists and Pediatric Rheumatologists: A Nationwide Multi-Center Retrospective Observational Study.
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In one paragraph
Article in Frontiers in pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 5 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 5 pooled it
23.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 5 syntheses or guidelines pooled it, 88 citations in OpenAlex.
- Off-label use of canakinumab in pediatric rheumatology and rare diseases.Frontiers in medicine · 2022Pooled it
- Biologic disease modifying antirheumatic drugs and Janus kinase inhibitors in paediatric rheumatology - what we know and what we do not know from randomized controlled trials.Pediatric rheumatology online journal · 2021Pooled it
- Revised recommendations of the Italian Society of Pediatrics about the general management of Kawasaki disease.Italian journal of pediatrics · 2021Guideline
- [Results of the systematic literature search as basis for the "Evidence-based treatment recommendations for familial Mediterranean fever patients with insufficient response or intolerability to colchicine" of the Society for Pediatric and Adolescent Rheumatology and the German Society for Rheumatology].Zeitschrift fur Rheumatologie · 2020Pooled it
- The right place of interleukin-1 inhibitors in the treatment of Behçet's syndrome: a systematic review.Rheumatology international · 2019Pooled it
- MIS-C, inherited metabolic diseases and methylmalonic acidemia: a case report and review of the literature.Italian journal of pediatrics · 2025Review
- Post-marketing safety of anakinra and canakinumab: a real-world pharmacovigilance study based on FDA adverse event reporting system.Frontiers in pharmacology · 2025Article
- Anakinra in the management of adult-onset still's disease: a single-center experience.Internal and emergency medicine · 2025Article
- Diagnosing and Treating Systemic Juvenile Idiopathic Arthritis and Adult-Onset Still's Disease as Part of the Still's Disease Continuum.Mediterranean journal of rheumatology · 2024Review
- Risk of Macrophage Activation Syndrome in Patients with Adult-Onset Still's Disease Treated with IL-1 and IL-6 Inhibitors: A Meta-analysis and Single-Center Experience.Rheumatology and therapy · 2023Article
- Treatment with Biologic Drugs in Pediatric Behçet's Disease: A Comprehensive Analysis of the Published Data.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2023Review
- Diagnosis and treatment of adult-onset Still's disease: a concise summary of the German society of rheumatology S2 guideline.Zeitschrift fur Rheumatologie · 2023Review
- Axial spondyloarthritis in patients with recurrent fever attacks: data from the AIDA network registry for undifferentiated autoInflammatory diseases (USAIDs).Frontiers in medicine · 2023Article
- Adult-Onset Still's Disease-A Complex Disease, a Challenging Treatment.International journal of molecular sciences · 2022Review
- Canakinumab as first-line biological therapy in Still's disease and differences between the systemic and the chronic-articular courses: Real-life experience from the international AIDA registry.Frontiers in medicine · 2022Article
- Anakinra in Paediatric Rheumatology and Periodic Fever Clinics: Is the Higher Dose Safe?Frontiers in pediatrics · 2022Article
- The everchanging framework of autoinflammation.Internal and emergency medicine · 2021Review
- Early introduction of anakinra improves acute pericarditis and prevents tamponade in Staphylococcal sepsis.Internal and emergency medicine · 2021Article
- Overview of the rarest causes of fever in newborns: handy hints for the neonatologist.Journal of perinatology : official journal of the California Perinatal Association · 2021Review
- Children and Adults with PFAPA Syndrome: Similarities and Divergences in a Real-Life Clinical Setting.Advances in therapy · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
48 authors at 20 institutions in 1 country.
Antonio VitaleDepartment of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, University of Siena Siena, Italy.
Antonella InsalacoDivision of Rheumatology, Department of Pediatric Medicine, IRCCS, Bambino Gesù Children's Hospital Rome, Italy.
Paolo SfrisoRheumatology Unit, Department of Medicine, University of Padua Padua, Italy.
Giuseppe LopalcoRheumatology Unit, Interdisciplinary Department of Medicine, University of Bari Bari, Italy.
Giacomo EmmiDepartment of Experimental and Clinical Medicine, University of Florence Florence, Italy.
Marco CattaliniPediatric Clinic, University of Brescia and Spedali Civili di Brescia Brescia, Italy.
Raffaele MannaPeriodic Fever Research Center, Institute of Internal Medicine, Università Cattolica Sacro Cuore, Fondazione Policlinico A. Gemelli Rome, Italy.
Rolando CimazPediatric Rheumatology Unit, AOU Meyer Florence, Italy.
Roberta PrioriDepartment of Internal Medicine and Medical Specialities, Rheumatology Unit, Sapienza University of Rome Rome, Italy.
Rosaria TalaricoRheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa Pisa, Italy.
Stefano GentileschiDepartment of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, University of Siena Siena, Italy.
Ginevra de MarchiDepartment of Medical and Biological Sciences, Rheumatology Clinic, University of Udine Udine, Italy.
Micol FrassiRheumatology and Clinical Immunology, Spedali Civili, and Department of Clinical and Experimental Sciences, University of Brescia Brescia, Italy.
Romina GallizziDepartment of Pediatrics, Azienda G. Martino, University of Messina Messina, Italy.
Alessandra SorianoRheumatology Unit, Department of Internal Medicine, Azienda Ospedaliera ASMN, Istituto di Ricovero e Cura a Carattere Scientifico Reggio Emilia, Italy.
Maria AlessioDepartment of Pediatrics, University Federico II of Naples Naples, Italy.
Daniele CammelliRheumatology Section, Immunoallergology Unit, AOU Careggi Florence, Italy.
Maria C MaggioUniversitary Department "Pro.S.A.M.I.", University of Palermo Palermo, Italy.
Renzo MarcolongoClinical Immunology, Department of Medicine, University of Padua Padua, Italy.
Francesco La TorreDepartment of Pediatrics, A. Perrino Hospital Brindisi, Italy.
Claudia FabianiDepartment of Ophthalmology, Humanitas Research Hospital Milan, Italy.
Serena ColafrancescoDepartment of Internal Medicine and Medical Specialities, Rheumatology Unit, Sapienza University of Rome Rome, Italy.
Francesca RicciPediatric Clinic, University of Brescia and Spedali Civili di Brescia Brescia, Italy.
Paola GalozziRheumatology Unit, Department of Medicine, University of Padua Padua, Italy.
Ombretta ViapianaRheumatology Section, Department of Medicine, University of Verona Verona, Italy.
Elena VerrecchiaPeriodic Fever Research Center, Institute of Internal Medicine, Università Cattolica Sacro Cuore, Fondazione Policlinico A. Gemelli Rome, Italy.
Manuela PardeoDivision of Rheumatology, Department of Pediatric Medicine, IRCCS, Bambino Gesù Children's Hospital Rome, Italy.
Lucia CerritoPeriodic Fever Research Center, Institute of Internal Medicine, Università Cattolica Sacro Cuore, Fondazione Policlinico A. Gemelli Rome, Italy.
Elena CavallaroDepartment of Medical and Biological Sciences, Rheumatology Clinic, University of Udine Udine, Italy.
Alma N OlivieriDipartimento della Donna, del Bambino e di Chirurgia Generale e Specialistica, Seconda Università degli Studi of Naples Naples, Italy.
Giuseppe PaolazziDepartment of Rheumatology, Santa Chiara Hospital Trento, Italy.
Gianfranco VitielloExperimental and Clinical Medicine Department, University of Florence Florence, Italy.
Armin MaierStruttura Semplice di Reumatologia, Ospedale di Bolzano Bolzano, Italy.
Elena SilvestriDepartment of Experimental and Clinical Medicine, University of Florence Florence, Italy.
Chiara StagnaroRheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa Pisa, Italy.
Guido ValesiniDepartment of Internal Medicine and Medical Specialities, Rheumatology Unit, Sapienza University of Rome Rome, Italy.
Marta MoscaRheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa Pisa, Italy.
Salvatore de VitaDepartment of Medical and Biological Sciences, Rheumatology Clinic, University of Udine Udine, Italy.
Angela TincaniRheumatology and Clinical Immunology, Spedali Civili, and Department of Clinical and Experimental Sciences, University of Brescia Brescia, Italy.
Giovanni LapadulaRheumatology Unit, Interdisciplinary Department of Medicine, University of Bari Bari, Italy.
Bruno FredianiDepartment of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, University of Siena Siena, Italy.
Fabrizio De BenedettiDivision of Rheumatology, Department of Pediatric Medicine, IRCCS, Bambino Gesù Children's Hospital Rome, Italy.
Florenzo IannoneRheumatology Unit, Interdisciplinary Department of Medicine, University of Bari Bari, Italy.
Leonardo PunziRheumatology Unit, Department of Medicine, University of Padua Padua, Italy.
Carlo SalvaraniRheumatology Unit, Department of Internal Medicine, Azienda Ospedaliera ASMN, Istituto di Ricovero e Cura a Carattere Scientifico Reggio Emilia, Italy.
Mauro GaleazziDepartment of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, University of Siena Siena, Italy.
Donato RigantePeriodic Fever Research Center, Institute of Pediatrics, Università Cattolica Sacro Cuore, Fondazione Policlinico A. Gemelli Rome, Italy.
Luca CantariniDepartment of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, University of Siena Siena, Italy.
University of Siena · ITUniversità Cattolica del Sacro Cuore · ITUniversity of Padua · ITSapienza University of Rome · ITUniversity of Bari Aldo Moro · ITUniversity of Brescia · ITUniversity of Florence · ITUniversity of Pisa · ITUniversity of Udine · ITBambino Gesù Children's Hospital · ITAzienda Ospedaliero-Universitaria Careggi · ITAzienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITIRCCS Humanitas Research Hospital · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITMeyer Children's Hospital · ITOspedale A. Perrino · ITOspedale di Bolzano · ITOspedale Santa Chiara · ITUniversity of Messina · ITUniversity of Naples Federico II · IT
Funding
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Abstract
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Indexed as
anakinraautoinflammatory disorderscanakinumabinterleukin (IL)-1treatment
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.