Evidence map›Paper›PMID 27822024›Full record

ReviewClinical interventions in aging2016

Animal models of frailty: current applications in clinical research.

Alice E Kane, Sarah N Hilmer, John Mach, Sarah J Mitchell, Rafael de Cabo, Susan E Howlett

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinical interventions in aging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alice E KaneDepartment of Pharmacology, Dalhousie University, Halifax, NS, Canada.
Sarah N HilmerKolling Institute of Medical Research and Sydney Medical School, University of Sydney; Department of Clinical Pharmacology; Department of Aged Care, Royal North Shore Hospital, Sydney, NSW, Australia.
John MachKolling Institute of Medical Research and Sydney Medical School, University of Sydney; Department of Clinical Pharmacology; Department of Aged Care, Royal North Shore Hospital, Sydney, NSW, Australia.
Sarah J MitchellNational Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Rafael de CaboNational Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Susan E HowlettDepartment of Pharmacology, Dalhousie University, Halifax, NS, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ethical, logistical, and biological complications of working with an older population of people inherently limits clinical studies of frailty. The recent development of animal models of frailty, and tools for assessing frailty in animal models provides an invaluable opportunity for frailty research. This review summarizes currently published animal models of frailty including the interleukin-10 knock-out mouse, the mouse frailty phenotype assessment tool, and the mouse clinical frailty index. It discusses both current and potential roles of these models in research into mechanisms of frailty, interventions to prevent/delay frailty, and the effect of frailty on outcomes. Finally, this review discusses some of the challenges and opportunities of translating research findings from animals to humans.

Indexed as

Frail ElderlyModels, AnimalAged, 80 and overAnimalsFemaleHumansMaleMiceMice, Inbred C57BLMice, Knockoutfrailty indexfrailty phenotypeIL-10 knock-outmouse models

Identifiers

PMID27822024
PMCPMC5089820

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.