ArticlePatient preference and adherence2016
Time to lack of persistence with pharmacological treatment among patients with current depressive episodes: a natural study with 1-year follow-up.
Article in Patient preference and adherence, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Clinical Predictors of Engagement in Teleintegrated Care and Telereferral Care for Complex Psychiatric Disorders in Primary Care: a Randomized Trial.Journal of general internal medicine · 2022Trial
- Patient Attitudes About Light Therapy and Negative Ion Therapy for Nonseasonal Depression: An Online Survey Study.Cureus · 2025Article
- Case Report: Paliperidone Palmitate in the Management of Bipolar I Disorder With Non-compliance.Frontiers in psychiatry · 2020Article
- Patterns of persistence with pharmacological treatment among patients with current depressive episode and their impact on long-term outcome: a naturalistic study with 5-year follow-up.Patient preference and adherence · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
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Abstract
introductionMedication nonadherence remains a big challenge for depressive patients. This study aims to assess and compare the medication persistence between unipolar depression (UD) and bipolar depression (BD).
methodsA total of 146 UD and 187 BD patients were recruited at their first index prescription. Time to lack of persistence with pharmacological treatment (defined as a gap of at least 60 days without taking any medication) was calculated, and clinical characteristics were collected. Final diagnosis was made at the end of 1-year follow-up.
resultsA total of 101 (69.2%) UD and 126 (67.4%) BD patients discontinued the treatment, with a median duration of 36 days and 27 days, respectively. No significant difference was found between UD and BD in terms of time to lack of persistence with pharmacological treatment. The highest discontinuation rate (>40%) occurred in the first 3 months for both groups of patients. For UD patients, those with a higher risk of suicide (odds ratio [OR] =0.696, LIMITATION: Conservative definition of nonadherence, low representativeness of sample.
conclusionTreatment discontinuation was frequently seen in patients with UD or BD, especially in the first 3 months of treatment. In spite of the similar pattern of medication persistence, UD and BD differ from each other in predictors of premature drop out.
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