ReviewJournal of orthopaedics2017
Osteomyelitis: Recent advances in pathophysiology and therapeutic strategies.
Review in Journal of orthopaedics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
99 citing papers in PubMed, 224 citations in OpenAlex.
- Evaluating the efficacy of combined flap coverage, antibiotic-loaded bone cement and negative pressure irrigation in traumatic osteomyelitis management.International wound journal · 2024Trial
- PET/CT-guided navigation-assisted debridement for tibial fracture-related infection: a retrospective cohort study.Journal of orthopaedic translation · 2026Article
- Current and emerging biomaterials for targeted drug delivery in osteomyelitis management.Discover nano · 2026Review
- Review
- Hardware-preserving management of early soft-tissue breakdown over stable osteosynthesis: a retrospective single-centre experience.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2026Article
- Dual-Functional Triphasic Composite Scaffolds for Enhanced Antibacterial and Osteogenic Performance in Preventing Osteomyelitis Recurrence.ACS omega · 2026Article
- How Bioactive Glass S53P4 Kills Bacteria.Journal of functional biomaterials · 2026Article
- Ilizarov Method for the Management of Infected Nonunion of the Femur With or Without Bony Defects.Cureus · 2026Article
- Managing Bone Infections Beyond Systemic Antibiotics: A Scoping Review.Pathogens (Basel, Switzerland) · 2026Review
- Osteomyelitis in HIV pathogenesis, challenges, and therapeutic strategies.Annals of medicine and surgery (2012) · 2026Review
- Osteomyelitis related lameness across animal species: pathophysiology, etiology, epidemiology and experimental model approaches.Frontiers in veterinary science · 2026Review
- Case Report: Distal tibial physeal injury secondary to conservative treatment of acute hematogenous osteomyelitis resulting in ankle deformity - highlighting the necessity of regular follow-up.Frontiers in surgery · 2026Article
- Epidemiology of civilian patients with acute conflict-related extremity injuries sustained in Syria and Iraq.PLOS global public health · 2026Article
- Low-velocity ballistic tibia fractures are predisposed to complications and experience more unplanned reoperations.Journal of clinical orthopaedics and trauma · 2025Article
- Predictive Value ofDiagnostics (Basel, Switzerland) · 2025Article
- Management of pathologic fracture of long bones as a complication of acute osteomyelitis: a challenging task for orthopedic surgeons.BMC musculoskeletal disorders · 2025Article
- Post-traumatic Cervical Osteomyelitis Masquerading as Neck Strain Following Minor Trauma: A Case Report.Cureus · 2025Article
- Application of Antimicrobial Peptides (AMPs) in Treatment of Osteomyelitis in Human and Veterinary Orthopedics.Journal of functional biomaterials · 2025Review
- Exosomes derived from bone marrow mesenchymal stem cells induce the proliferation and osteogenic differentiation and regulate the inflammatory state in osteomyelitis in vitro model.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Nanomaterial-mediated antibiotic delivery: a novel strategy for osteomyelitis therapy.Frontiers in bioengineering and biotechnology · 2025Review
39 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
This review article summarizes the recent advances in pathogenic mechanisms and novel therapeutic strategies for osteomyelitis, covering both periprosthetic joint infections and fracture-associated bone infections. A better understanding of the pathophysiology including the mechanisms for biofilm formation has led to new therapeutic strategies for this devastating disease. Research on novel local delivery materials with appropriate mechanical properties, lower exothermicity, controlled release of antibiotics, and absorbable scaffolding for bone regeneration is progressing rapidly. Emerging strategies for prevention, early diagnosis of low-grade infections, and innovative treatments of osteomyelitis such as biofilm disruptors and immunotherapy are highlighted in this review.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.