Evidence map›Paper›PMID 27821903›Full record

ReviewDisease markers2016

Proteomic Approaches to Biomarker Discovery in Cutaneous T-Cell Lymphoma.

Alexandra Ion, Iris Maria Popa, Laura Maria Lucia Papagheorghe, Cristina Lisievici, Mihai Lupu, Vlad Voiculescu, Constantin Caruntu, Daniel Boda

Open access · hybridAbstract readReview
In one paragraph

Review in Disease markers, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
5.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
  2. Diabetic neuropathy: A NRF2 disease?Journal of diabetes · 2024
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  3. Article
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  6. Cannabinoids and Inflammations of the Gut-Lung-Skin Barrier.Journal of personalized medicine · 2021
    Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Somatostatinoma: Beyond neurofibromatosis type 1 (Review).Experimental and therapeutic medicine · 2020
    Review
  13. Review
  14. Article
  15. Clinical features in toxic coma in children.Experimental and therapeutic medicine · 2019
    Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Alexandra IonDepartment of Dermatology and Allergology, Elias Emergency University Hospital, 011461 Bucharest, Romania.ORCID 0000-0002-1749-4102
Iris Maria PopaDepartment of Plastic and Reconstructive Surgery, "Bagdasar Arseni" Clinical Emergency Hospital, 041915 Bucharest, Romania.ORCID 0000-0001-7702-448X
Laura Maria Lucia PapagheorgheDepartment of Dermatology and Allergology, Elias Emergency University Hospital, 011461 Bucharest, Romania.
Cristina LisieviciDepartment of Dermatology and Allergology, Elias Emergency University Hospital, 011461 Bucharest, Romania.
Mihai LupuDepartment of Dermatology and Allergology, Elias Emergency University Hospital, 011461 Bucharest, Romania.ORCID 0000-0002-5438-0817
Vlad VoiculescuDepartment of Dermatology and Allergology, Elias Emergency University Hospital, 011461 Bucharest, Romania.ORCID 0000-0002-5671-9378
Constantin CaruntuDepartment of Physiology, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania; Department of Dermatology, "Prof. N. C. Paulescu" National Institute of Diabetes, Nutrition and Metabolic Diseases, 020475 Bucharest, Romania.ORCID 0000-0003-4530-7965
Daniel BodaDermatology Research Laboratory, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania; Department of Dermatology, Carol Medical Center, 020915 Bucharest, Romania.ORCID 0000-0003-3282-3426
Clinical Emergency Hospital Bucharest · ROCarol Davila University of Medicine and Pharmacy · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cutaneous T-cell lymphoma (CTCL) is the most frequently encountered type of skin lymphoma in humans. CTCL encompasses multiple variants, but the most common types are mycosis fungoides (MF) and Sezary syndrome (SS). While most cases of MF run a mild course over a period of many years, other subtypes of CTCL are very aggressive. The rapidly expanding fields of proteomics and genomics have not only helped increase knowledge concerning the carcinogenesis and tumor biology of CTCL but also led to the discovery of novel markers for targeted therapy. Although multiple biomarkers linked to CTCL have been known for a relatively long time (e.g., CD25, CD45, CD45RA, and CD45R0), compared to other cancers (lymphoma, melanoma, colon carcinoma, head and neck cancer, renal cancer, and cutaneous B-cell lymphoma), information about the antigenicity of CTCL remains relatively limited and no dependable protein marker for CTCL has been discovered. Considering the aggressive nature of some types of CTCL, it is necessary to identify circulating molecules that can help in the early diagnosis, differentiation from inflammatory skin diseases (psoriasis, nummular eczema), and aid in predicting the prognosis and evolution of this pathology. This review aims to bring together some of the information concerning protein markers linked to CTCL, in an effort to further the understanding of the convolute processes involved in this complex pathology.

Indexed as

Biomarkers, TumorHumansLymphoma, T-Cell, CutaneousProteomicsSkin NeoplasmsBiomarkers, Tumor

Identifiers

PMID27821903
PMCPMC5086377
OpenAlexW2531523857

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.