Evidence map›Paper›PMID 27821902›Full record

ArticleDisease markers2016

RANTES Gene Polymorphisms Associated with HIV-1 Infections in Kenyan Population.

Shem P M Mutuiri, Helen L Kutima, Lamech M Mwapagha, James K Munyao, Anthony Kebira Nyamache, Irene Wanjiru, Samoel A Khamadi

Erratum issuedOpen access · hybridAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Disease markers, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Shem P M MutuiriInstitute of Tropical Medicine and Infectious Diseases, Jomo Kenyatta University of Agriculture and Technology, Juja, Kenya.
Helen L KutimaInstitute of Tropical Medicine and Infectious Diseases, Jomo Kenyatta University of Agriculture and Technology, Juja, Kenya.
Lamech M MwapaghaInstitute of Tropical Medicine and Infectious Diseases, Jomo Kenyatta University of Agriculture and Technology, Juja, Kenya.ORCID 0000-0003-1048-1787
James K MunyaoInstitute of Biotechnology, Jomo Kenyatta University of Agriculture and Technology, Juja, Kenya.
Anthony Kebira NyamacheDepartment of Plant and Microbial Sciences, Kenyatta University, Nairobi, Kenya.
Irene WanjiruDepartment of Plant and Microbial Sciences, Kenyatta University, Nairobi, Kenya.
Samoel A KhamadiCenter for Virus Research, Kenya Medical Research Institute, Nairobi, Kenya.ORCID 0000-0003-3050-5977
Jomo Kenyatta University of Agriculture and Technology · KEKenyatta University · KEKenya Medical Research Institute · KE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous studies have reported that two single nucleotide polymorphisms (SNPs) in the RANTES gene promoter region, -403G/A and -28C/G, are associated with a slower rate of decline in CD4+ T cell count. In addition, as a ligand of the major HIV coreceptor CCR5, it is known to block HIV-CCR5 interactions in the course of the HIV infection cycle. This study was carried out with the aim of determining the occurrence of single nucleotide polymorphisms (SNPs) -403G > A and -28C > G in the promoter region of RANTES, in a subset of the Kenyan population. Genomic DNA was extracted from peripheral blood monocular cells and used to amplify the RANTES gene region. Restriction fragment length polymorphism was used to determine the genotypes of the RANTES gene. Out of 100 HIV infected individuals, 19% had G1 genotypes (403G/G, 28C/G), 30% (403A/A, 28C/C), and 50% (403G/A, 28C/C), while in healthy blood donors 13% had G4 (403G/A, 28C/C) genotypes, 22% (403A/A, 28C/C), and 54% (403G/A, 28C/C). HIV negative blood donors (54%) had higher risk of alteration to risk of HIV transmission compared to those who were HIV infected (50%). However, the risk to transmission and distribution differences was not significant (

Indexed as

AdolescentAdultBiomarkersCase-Control StudiesChemokine CCL5FemaleFollow-Up StudiesGenetic Predisposition to DiseaseGenotypeHIV-1HIV InfectionsHumansKenyaMalePolymorphism, Restriction Fragment LengthPolymorphism, Single NucleotideBiomarkersCCL5 protein, humanChemokine CCL5

Identifiers

PMID27821902
PMCPMC5086385
OpenAlexW2531056260

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.