SynthesisBulletin of the World Health Organization2016
Times to key events in Zika virus infection and implications for blood donation: a systematic review.
Synthesis in Bulletin of the World Health Organization, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- A systematic review and evaluation of Zika virus forecasting and prediction research during a public health emergency of international concern.PLoS neglected tropical diseases · 2019Pooled it
- Prevalence of Zika virus in blood donations: a systematic review and meta-analysis.BMC infectious diseases · 2019Pooled it
- Dengue and Zika Virus Diagnostic Testing for Patients with a Clinically Compatible Illness and Risk for Infection with Both Viruses.MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2019Guideline
- Sexual transmission of Zika virus and other flaviviruses: A living systematic review.PLoS medicine · 2018Pooled it
- Acute Zika virus infection in an asymptomatic blood donor at the onset of the Puerto Rico epidemic.Transfusion · 2019Trial
- A New Threat on the Rise: Oropouche Viral Infection.Annals of African medicine · 2026Review
- Combining machine learning and dynamic system techniques to early detection of respiratory outbreaks in routinely collected primary healthcare records.BMC medical research methodology · 2025Article
- Best practices for estimating and reporting epidemiological delay distributions of infectious diseases.PLoS computational biology · 2024Article
- Envelope Protein-Targeting Zika Virus Entry Inhibitors.International journal of molecular sciences · 2024Review
- Comparative Evaluation of Select Serological Assays for Zika Virus Using Blinded Reference Panels.Viruses · 2024Article
- Article
- Climate-driven mosquito-borne viral suitability index: measuring risk transmission of dengue, chikungunya and Zika in Mexico.International journal of health geographics · 2022Article
- Estimating the effective reproduction number for heterogeneous models using incidence data.Royal Society open science · 2022Article
- Article
- Game-Theoretical Model of the Voluntary Use of Insect Repellents to Prevent Zika Fever.Dynamic games and applications · 2022Article
- SARS-CoV-2, Zika viruses and mycoplasma: Structure, pathogenesis and some treatment options in these emerging viral and bacterial infectious diseases.Biochimica et biophysica acta. Molecular basis of disease · 2021Article
- Advances and insights in the diagnosis of viral infections.Journal of nanobiotechnology · 2021Review
- Effects of changes in temperature on Zika dynamics and control.Journal of the Royal Society, Interface · 2021Article
- Estimating incidence of infection from diverse data sources: Zika virus in Puerto Rico, 2016.PLoS computational biology · 2021Article
- Zika virus pathogenesis and current therapeutic advances.Pathogens and global health · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
objectiveTo estimate the timing of key events in the natural history of Zika virus infection.
methodsIn February 2016, we searched PubMed, Scopus and the Web of Science for publications containing the term
findingsWe identified 20 articles on 25 patients with Zika virus infection. The median incubation period for the infection was estimated to be 5.9 days (95% credible interval, CrI: 4.4-7.6), with 95% of people who developed symptoms doing so within 11.2 days (95% CrI: 7.6-18.0) after infection. On average, seroconversion occurred 9.1 days (95% CrI: 7.0-11.6) after infection. The virus was detectable in blood for 9.9 days (95% CrI: 6.9-21.4) on average. Without screening, the estimated risk that a blood donation would come from an infected individual increased by approximately 1 in 10 000 for every 1 per 100 000 person-days increase in the incidence of Zika virus infection. Symptom-based screening may reduce this rate by 7% (relative risk, RR: 0.93; 95% CrI: 0.89-0.99) and antibody screening, by 29% (RR: 0.71; 95% CrI: 0.28-0.88).
conclusionNeither symptom- nor antibody-based screening for Zika virus infection substantially reduced the risk that blood donations would be contaminated by the virus. Polymerase chain reaction testing should be considered for identifying blood safe for use in pregnant women in high-incidence areas.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.