ArticleBulletin of the World Health Organization2016
Measuring Haitian children's exposure to chikungunya, dengue and malaria.
Article in Bulletin of the World Health Organization, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- The impact of school water, sanitation, and hygiene improvements on infectious disease using serum antibody detection.PLoS neglected tropical diseases · 2018Trial
- Integrated Serosurveillance of Infectious Diseases Using Multiplex Bead Assays: A Systematic Review.Tropical medicine and infectious disease · 2025Review
- Chikungunya Outbreak Risks after the 2014 Outbreak, Dominican Republic.Emerging infectious diseases · 2024Article
- Adaptation to a Multiplex Bead Assay and Seroprevalence to Rift Valley Fever N Protein: Nampula Province, Mozambique, 2013-2014.Journal of virology · 2022Article
- Integrated serological surveillance of acute febrile illness in the context of a lymphatic filariasis survey in Timor-Leste: a pilot study using dried blood spots.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2022Article
- Antenatal Seroprevalence of Zika and Chikungunya Viruses, Kingston Metropolitan Area, Jamaica, 2017-2019.Emerging infectious diseases · 2022Article
- Multiplex Serology for Measurement of IgG Antibodies Against Eleven Infectious Diseases in a National Serosurvey: Haiti 2014-2015.Frontiers in public health · 2022Article
- Anti-chikungunya virus seroprevalence in Indigenous groups in the São Francisco Valley, Brazil.PLoS neglected tropical diseases · 2021Article
- Determining seropositivity-A review of approaches to define population seroprevalence when using multiplex bead assays to assess burden of tropical diseases.PLoS neglected tropical diseases · 2021Review
- Serological Data Shows Low Levels of Chikungunya Exposure in Senegalese Nomadic Pastoralists.Pathogens (Basel, Switzerland) · 2019Article
- Optimisation and standardisation of a multiplex immunoassay of diverseWellcome open research · 2019Article
- Current challenges and implications for dengue, chikungunya and Zika seroprevalence studies worldwide: A scoping review.PLoS neglected tropical diseases · 2018Article
- Integrated Serologic Surveillance of Population Immunity and Disease Transmission.Emerging infectious diseases · 2018Article
- Use of Bead-Based Serologic Assay to Evaluate Chikungunya Virus Epidemic, Haiti.Emerging infectious diseases · 2018Article
- Measuring changes in transmission of neglected tropical diseases, malaria, and enteric pathogens from quantitative antibody levels.PLoS neglected tropical diseases · 2017Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo differentiate exposure to the newly introduced chikungunya virus from exposure to endemic dengue virus and other pathogens in Haiti.
methodsWe used a multiplex bead assay to detect immunoglobulin G (IgG) responses to a recombinant chikungunya virus antigen, two dengue virus-like particles and three recombinant
findingsOf the samples from the longitudinal cohort, none of the 153 collected between 2011 and 2013 but 78.7% (48/61) of those collected in 2014 were positive for IgG responses to the chikungunya virus antigen. In the cross-sectional sample, such responses were detected in 96 (75.6%) of the children and occurred at similar prevalence across all age groups. In the same sample, responses to malarial antigen were only detected in eight children (6.3%) but the prevalence of IgG responses to dengue virus antigens was 60.6% (77/127) overall and increased steadily with age. Spatial analysis indicated that the prevalence of IgG responses to the chikungunya virus and one of the dengue virus-like particles decreased as the sampling site moved away from the city of Léogâne and towards the ocean.
conclusionSerological evidence indicates that there had been a rapid and intense dissemination of chikungunya virus in Haiti. The multiplex bead assay appears to be an appropriate serological platform to monitor the seroprevalence of multiple pathogens simultaneously.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.