Evidence map›Paper›PMID 27821808›Full record

ArticleOncotarget2016

Association of serum 25-hydroxyvitamin D status with bone mineral density in 0-7 year old children.

Yanrong Fu, Youfang Hu, Zhenying Qin, Yan Zhao, Zi Yang, Yinfang Li, Guanyu Liang, Heyun Lv, Hong Hong, Yuan Song and 12 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 3 pooled it
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 3 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 9 institutions in 1 country.

Yanrong FuDepartment of Child Health Care, the Second Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, 210011, China.
Youfang HuDepartment of Child Health Care, Jiangsu Women and Children Health Hospital, Women and Child Branch Hospital of Jiangsu Province Hospital, the First Affiliated Hospital with Nanjing Medical University, Nanjing, 210036, China.
Zhenying QinDepartment of Child Health Care, Jiangsu Women and Children Health Hospital, Women and Child Branch Hospital of Jiangsu Province Hospital, the First Affiliated Hospital with Nanjing Medical University, Nanjing, 210036, China.
Yan ZhaoDepartment of Child Health Care, Jiangsu Women and Children Health Hospital, Women and Child Branch Hospital of Jiangsu Province Hospital, the First Affiliated Hospital with Nanjing Medical University, Nanjing, 210036, China.
Zi YangDepartment of Child Health Care, Jiangsu Women and Children Health Hospital, Women and Child Branch Hospital of Jiangsu Province Hospital, the First Affiliated Hospital with Nanjing Medical University, Nanjing, 210036, China.
Yinfang LiDepartment of Pediatrics, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, China.
Guanyu LiangDepartment of Child Health Care, Jiangsu Women and Children Health Hospital, Women and Child Branch Hospital of Jiangsu Province Hospital, the First Affiliated Hospital with Nanjing Medical University, Nanjing, 210036, China.
Heyun LvDepartment of Child Health Care, Jiangning Maternity and Child Health Care Institute, Nanjing, 211100, China.
Hong HongDepartment of Child Health Care, Drum Tower Maternity and Child Health Care Institute, Nanjing, 210009, China.
Yuan SongDepartment of Child Health Care, Suzhou Municipal Hospital, Suzhou, 215000, China.
Yarong WeiDepartment of Child Health Care, Wuxi Maternity and Child Health Care Hospital, Wuxi, 214000, China.
Hongni YueDepartment of Child Health Care, Huai'an Maternity and Child Health Care Hospital, Huai'an, 223001, China.
Wen ZhengDepartment of Child Health Care, Yancheng Maternity and Child Health Care Institute, Yancheng, 224000, China.
Guoqin LiuDepartment of Child Health Care, Dafeng Maternity and Child Health Care Hospital, Dafeng, 224100, China.
Yufei NiDepartment of Child Health Care, Nantong Maternity and Child Health Care Hospital, Nantong, 226000, China.
Mei ZhuDepartment of Child Health Care, Xuzhou Children's Hospital, Xuzhou, 221000, China.
Aiping WuDepartment of Child Health Care, Xinghua Maternity and Child Health Care Hospital, Xinghua, 225700, China.
Juhua YanDepartment of Child Health Care, Kunshan Maternity and Child Health Care Institute, Kunshan, 215300, China.
Chenbo JiNanjing Maternity and Child Health Care Institute, Nanjing Maternity and Child Health Care Hospital, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing, 210029, China.
Xirong GuoNanjing Maternity and Child Health Care Institute, Nanjing Maternity and Child Health Care Hospital, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing, 210029, China.
Juan WenNanjing Maternity and Child Health Care Institute, Nanjing Maternity and Child Health Care Hospital, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing, 210029, China.
Rui QinDepartment of Child Health Care, Jiangsu Women and Children Health Hospital, Women and Child Branch Hospital of Jiangsu Province Hospital, the First Affiliated Hospital with Nanjing Medical University, Nanjing, 210036, China.
Nanjing Maternity and Child Health Care Hospital · CNNanjing Medical University · CNJiangsu Province Hospital · CNNantong University · CNSecond People’s Hospital of Huai’an · CNSuzhou Municipal Hospital · CNXuzhou Children Hospital · CNYancheng Second People's Hospital · CNYunnan Maternal and Child Health · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo describe the status of serum 25-hydoxyvitamin D [25(OH)D] concentrations and identify the relationship between 25(OH)D and bone mineral density (BMD). In an effort to explore the appropriate definition of vitamin D (VD) deficiency in 0-7 year old children.

resultsThe median serum 25(OH)D concentrations was 62.9 nmol/L and 28.9% of the children had a low 25(OH)D (< 50 nmol/L). And a linear relation between 25(OH)D concentrations and BMD was surveyed (r = 0.144 , P < 0.001). After adjusting for the confounders, serum 25(OH)D was positively associated with BMD (β = 172.0, 95%CI = 142.8-201.2, P < 0.001), and low 25(OH)D (< 75 nmol/L) had a high stake for low BMD (OR = 1.424, 95%CI = 1.145-1.769, P = 0.001). Additionally, there was a nonlinear relation between 25(OH)D and low BMD, and a critical value for 25(OH)D of 75 nmol/L appeared for low BMD. The prevalence of low BMD was 14.1% in children with 25(OH)D ≥ 75 nmol/L, much lower than that of the concentrations between 50-75 nmol/L and < 50 nmol/L. MATERIALS AND

methodsA total of 4,846 children 0-7 years old were recruited in Jiangsu Province, China. BMD and serum 25(OH)D concentrations were determined by quantitative ultrasound and enzyme-linked immunosorbent assay, respectively. Linear regression and logistic regression analyses were used to assess the association of 25(OH)D concentrations with BMD.

conclusionsSerum 25(OH)D concentrations was related with BMD and 25(OH)D concentrations < 75 nmol/L might be a more appropriate definition of VD deficiency in 0-7 year old children.

Indexed as

Bone DensityAge FactorsBiomarkersCase-Control StudiesChildChild, PreschoolChinaEnzyme-Linked Immunosorbent AssayFemaleHealth StatusHumansInfantInfant, NewbornLinear ModelsLogistic ModelsMale25-hydroxyvitamin DBiomarkersVitamin D0-7 year old childrenbone mineral densityserum 25-hydoxyvitamin D

Identifiers

PMID27821808
PMCPMC5348357
OpenAlexW2547289291

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.