Evidence map›Paper›PMID 27821804›Full record

SynthesisOncotarget2016

Tumor necrosis factor-alpha promoter polymorphism 308 G/A is not significantly associated with esophageal cancer risk: a meta-analysis.

Ming Luo, Yuan Yang, Dongmei Luo, Liang Liu, Yuening Zhang, Feifan Xiao, Jingcheng Yang, Chengdong Zhang, Shen Fu, Zhiguo Luo

Open access · diamondAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 3 pooled it
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 3 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Genetic association betweenOncotarget · 2017
    Pooled it
  3. Pooled it
  4. Review
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Ming LuoDepartment of Clinical Oncology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China.
Yuan YangSchool of Life Sciences, Fudan University, Shanghai, China.
Dongmei LuoSchool of Mathematics and Physics, Anhui University of technology, Maanshan, Anhui, China.
Liang LiuDepartment of Oncology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China.
Yuening ZhangMedical Scientific Research Center, Guangxi Medical University, Nanning, Guangxi, China.
Feifan XiaoMedical Scientific Research Center, Guangxi Medical University, Nanning, Guangxi, China.
Jingcheng YangSchool of Life Sciences, Fudan University, Shanghai, China.
Chengdong ZhangDepartment of Clinical Oncology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China.
Shen FuDepartment of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Shanghai, China.
Zhiguo LuoDepartment of Clinical Oncology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China.
Fudan University · CNFudan University Shanghai Cancer Center · CNGuangxi Medical University · CNTaihe Hospital · CNAnhui University of Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many studies have investigated the association between Tumor necrosis factor-α-308 G>A (rs1800629) and the risk of esophageal cancer. However, their results are inconsistent. Therefore, we performed a meta-analysis of available data to investigate any possible association between this polymorphism and esophageal cancer risk. We searched PubMed, EMBASE, Web of Science, and the CNKI database for articles published up to 2016. Crude and adjusted odds ratio with 95% confidence intervals were calculated using fixed or random effects models. We used a dominant model (GA+AA vs GG), a recessive model (AA vs GG+GA), an over-dominant model (GG+AA vs GA), and allele frequency (G vs A) to identify any association. Eleven studies with 5617 participants were included in the meta-analysis. Our results suggest that TNF-α-308 G>A (rs1800629) is not significantly associated with a risk of esophageal squamous cell carcinoma and esophageal adenocarcinoma. For genetic association studies, negative results of meta-analysis have a high level of evidence, and these results are important in this era of high-throughput sequencing-based precision medicine.

Indexed as

Polymorphism, Single NucleotidePromoter Regions, GeneticAdenocarcinomaCarcinoma, Squamous CellCase-Control StudiesDNA Mutational AnalysisEsophageal NeoplasmsEsophageal Squamous Cell CarcinomaFemaleGene FrequencyGenetic Association StudiesGenetic Predisposition to DiseaseHigh-Throughput Nucleotide SequencingHumansMaleTumor Necrosis Factor-alphaTNF protein, humanTumor Necrosis Factor-alphaassociationesophageal cancermeta-analysisriskTNF-α-308 G/A

Identifiers

PMID27821804
PMCPMC5346759
OpenAlexW2547045413

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.