Evidence map›Paper›PMID 27821745›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2016

Distinct regions that control ion selectivity and calcium-dependent activation in the bestrophin ion channel.

George Vaisey, Alexandria N Miller, Stephen B Long

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 66 citations in OpenAlex.

  1. Review
  2. Article
  3. The pentameric chloride channel BEST1 is activated by extracellular GABA.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Electronic Polarizability Tunes the Function of the Human Bestrophin 1 ClJournal of chemical theory and computation · 2025
    Article
  5. Article
  6. Electronic Polarizability Tunes the Function of the Human Bestrophin 1 ClbioRxiv : the preprint server for biology · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Glutamate Permeability of Chicken Best1.Experimental neurobiology · 2022
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

George VaiseyStructural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Alexandria N MillerStructural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Stephen B LongStructural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065; longs@mskcc.org.
Memorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Overall EvaluationP41GM103403 · NIGMS · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2012 to 2017
$14.3M
Structure and function of retinal calcium-activated chloride channelsR01GM110396 · NIGMS · SLOAN-KETTERING INST CAN RESEARCH · PI LONG, STEPHEN BARSTOW · 2015 to 2018
$2.0M
Pixel Array Detector for X-ray CrystallographyS10RR029205 · NCRR · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2010 to 2010
$1.8M
NCI NIH HHS P30 CA008748NCRR NIH HHS S10 RR029205NIGMS NIH HHS P41 GM103403NIGMS NIH HHS R01 GM110396
6 · The paper itself

Abstract

Cytoplasmic calcium (Ca

Indexed as

AlanineAmino Acid SubstitutionAnimalsBestrophinsCalciumChickensChloride ChannelsCrystallography, X-RayCytoplasmModels, MolecularProtein ConformationAlanineBestrophinsCalciumChloride ChannelsCaCCcalcium-activated chloride channelchannel gatingion channel biophysicsion selectivity

Identifiers

PMID27821745
PMCPMC5127342
OpenAlexW2557222554

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.