Evidence map›Paper›PMID 27821736›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2016

C-terminal domain of mammalian complexin-1 localizes to highly curved membranes.

Jihong Gong, Ying Lai, Xiaohong Li, Mengxian Wang, Jeremy Leitz, Yachong Hu, Yunxiang Zhang, Ucheor B Choi, Daniel Cipriano, Richard A Pfuetzner and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 87 citations in OpenAlex.

  1. Article
  2. Article
  3. Investigating Complexin-Membrane Interactions Using NMR and Optical Methods.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  4. Review
  5. Article
  6. Review
  7. Exploring Intrinsic Disorder in Human Synucleins and Associated Proteins.International journal of molecular sciences · 2024
    Article
  8. Synaptophysin chaperones the assembly of 12 SNAREpins under each ready-release vesicle.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  9. Neutral lysophosphatidylcholine mediates α-synuclein-induced synaptic vesicle clustering.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. The Core Complex of the CaJournal of molecular biology · 2023
    Review
  18. Article
  19. Article
  20. SNARE Proteins in Synaptic Vesicle Fusion.Advances in neurobiology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Jihong GongKey Laboratory of Cognitive Science, College of Biomedical Engineering, South-Central University for Nationalities, Wuhan 430074, China.
Ying LaiDepartment of Molecular and Cellular Physiology, Stanford University, Stanford, CA 94305.
Xiaohong LiKey Laboratory of Cognitive Science, College of Biomedical Engineering, South-Central University for Nationalities, Wuhan 430074, China.
Mengxian WangKey Laboratory of Cognitive Science, College of Biomedical Engineering, South-Central University for Nationalities, Wuhan 430074, China.
Jeremy LeitzDepartment of Molecular and Cellular Physiology, Stanford University, Stanford, CA 94305.
Yachong HuCenter for Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China.
Yunxiang ZhangDepartment of Molecular and Cellular Physiology, Stanford University, Stanford, CA 94305.
Ucheor B ChoiDepartment of Molecular and Cellular Physiology, Stanford University, Stanford, CA 94305.
Daniel CiprianoDepartment of Molecular and Cellular Physiology, Stanford University, Stanford, CA 94305.
Richard A PfuetznerDepartment of Molecular and Cellular Physiology, Stanford University, Stanford, CA 94305.
Thomas C SüdhofDepartment of Molecular and Cellular Physiology, Stanford University, Stanford, CA 94305.
Xiaofei YangKey Laboratory of Cognitive Science, College of Biomedical Engineering, South-Central University for Nationalities, Wuhan 430074, China; sunlittlefly@hotmail.com brunger@stanford.edu diaojj@gmail.com.
Axel T BrungerDepartment of Molecular and Cellular Physiology, Stanford University, Stanford, CA 94305; sunlittlefly@hotmail.com brunger@stanford.edu diaojj@gmail.com.
Jiajie DiaoDepartment of Molecular and Cellular Physiology, Stanford University, Stanford, CA 94305; sunlittlefly@hotmail.com brunger@stanford.edu diaojj@gmail.com.ORCID 0000-0003-4288-3203
Howard Hughes Medical Institute · USSouth Central Minzu University · CNStanford University · USXi'an Jiaotong University · CN

Funding

Single molecule studies of SNARE-induced vesicle fusionR37MH063105 · NIMH · STANFORD UNIVERSITY · PI BRUNGER, AXEL T · 2011 to 2020
$4.7M
NIMH NIH HHS R37 MH063105
6 · The paper itself

Abstract

In presynaptic nerve terminals, complexin regulates spontaneous "mini" neurotransmitter release and activates Ca

Indexed as

Adaptor Proteins, Vesicular Transportalpha-SynucleinAnimalsCalciumCell MembraneCells, CulturedMiceNerve Tissue ProteinsNeuronsRatsSNARE ProteinsSynaptic VesiclesSynaptotagminsAdaptor Proteins, Vesicular Transportalpha-SynucleinCalciumcomplexin INerve Tissue ProteinsSNARE ProteinsSynaptotagminscomplexinmembrane fusionneurotransmitter releaseSNAREssynaptic vesicle fusion

Identifiers

PMID27821736
PMCPMC5127347
OpenAlexW2552713810

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.