Evidence map›Paper›PMID 27821697›Full record

ArticleThe American journal of tropical medicine and hygiene2017

Dengue and West Nile Virus Transmission in Children and Adults in Coastal Kenya.

David M Vu, Tamara Banda, Crystal Y Teng, Chelsea Heimbaugh, Eric M Muchiri, Peter L Mungai, Francis M Mutuku, Julie Brichard, Ginny Gildengorin, Erin M Borland and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Temporal Variation and Human Host Predominance inPathogens (Basel, Switzerland) · 2025
    Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Oviposition Preferences of Aedes aegypti in Msambweni, Kwale County, Kenya.Journal of the American Mosquito Control Association · 2023
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. High Frequency of Antibiotic Prescription in Children With Undifferentiated Febrile Illness in Kenya.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

David M VuDepartment of Pediatrics, Stanford University School of Medicine, Stanford, California. davidvu@stanford.edu.
Tamara BandaCenter for Immunobiology and Vaccine Development, Children's Hospital Oakland Research Institute, Oakland, California.
Crystal Y TengCenter for Immunobiology and Vaccine Development, Children's Hospital Oakland Research Institute, Oakland, California.
Chelsea HeimbaughCenter for Immunobiology and Vaccine Development, Children's Hospital Oakland Research Institute, Oakland, California.
Eric M MuchiriDivision of Vector Borne and Neglected Tropical Diseases, Ministry of Health, Nairobi, Kenya.
Peter L MungaiCase Western Reserve University, Cleveland, Ohio.
Francis M MutukuEmory University, Atlanta, Georgia.
Julie BrichardCenter for Immunobiology and Vaccine Development, Children's Hospital Oakland Research Institute, Oakland, California.
Ginny GildengorinCenter for Immunobiology and Vaccine Development, Children's Hospital Oakland Research Institute, Oakland, California.
Erin M BorlandCenters for Disease Control and Prevention, Fort Collins, Colorado.
Ann M PowersCenters for Disease Control and Prevention, Fort Collins, Colorado.
Uriel KitronEmory University, Atlanta, Georgia.
Charles H KingCase Western Reserve University, Cleveland, Ohio.
A Desiree LaBeaudDepartment of Pediatrics, Stanford University School of Medicine, Stanford, California.
Case Western Reserve University · USCenters for Disease Control and Prevention · USEmory University · USStanford University · USMinistry of Health · KE

Funding

Spectrum Stanford Center for clinical and Translational Research and EducationUL1TR001085 · NCATS · STANFORD UNIVERSITY · PI CULLEN, MARK RICHARD, GREENBERG, HARRY BERNARD · 2013 to 2017
$37.1M
The child health impacts of overlapping vector-borne diseases in KenyaR01AI102918 · NIAID · STANFORD UNIVERSITY · PI Angelle Desiree LaBeaud · 2013 to 2026
$7.7M
Spectrum Stanford Center for clinical and Translational Research and EducationKL2TR001083 · NCATS · STANFORD UNIVERSITY · PI CULLEN, MARK RICHARD, GREENBERG, HARRY BERNARD · 2013 to 2017
$4.9M
NCATS NIH HHS KL2 TR001083NCATS NIH HHS UL1 TR001085NIAID NIH HHS L40 AI057605NIAID NIH HHS R01 AI102918
6 · The paper itself

Abstract

Dengue virus (DENV) and West Nile virus (WNV) are important reemerging arboviruses that are under-recognized in many parts of Africa due to lack of surveillance. As a part of a study on flavivirus, alphavirus, and parasite exposure in coastal Kenya, we measured neutralizing antibody against DENV and, to evaluate assay specificity, WNV in serum samples that tested positive for serum anti-DENV IgG by enzyme-linked immunosorbent assay. Of 830 anti-DENV IgG-positive samples that were tested for neutralizing activity, 488 (58.8%) neutralized DENV and 94 (11.3%) neutralized WNV. Of children ≤ 10 years of age, 23% and 17% had serum neutralizing antibody to DENV and WNV, respectively, indicating that DENV and WNV transmission has occurred in this region within the past decade. The results suggest that ongoing DENV and WNV transmission continues on the coast of Kenya and supports a need for routine arboviral surveillance in the area to detect and respond to future outbreaks.

Indexed as

AdolescentAdultAgedAged, 80 and overAntibodies, NeutralizingAntibodies, ViralChildChild, PreschoolDengueHumansInfantKenyaMiddle AgedWest Nile FeverYoung AdultAntibodies, NeutralizingAntibodies, Viral

Identifiers

PMID27821697
PMCPMC5239681
OpenAlexW2556791575

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.