ArticleInnate immunity2017
Zinc supplementation leads to immune modulation and improved survival in a juvenile model of murine sepsis.
Article in Innate immunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 36 citations in OpenAlex.
- Master transcriptional regulator SaeS inVirulence · 2025Article
- Serum zinc dynamics as a diagnostic and immunomodulatory biomarker in neonatal sepsis.Scientific reports · 2025Article
- Zinc deficiency as possible link between immunosenescence and age-related diseases.Immunity & ageing : I & A · 2025Review
- Potential Therapeutic Effect of ZnO/CuO Nanocomposite as an Acaricidal, Immunostimulant, and Antioxidant in Rabbits.Veterinary sciences · 2025Article
- Nutrients and rheumatoid arthritis: From the perspective of neutrophils.Frontiers in immunology · 2023Review
- Antiviral and immunological activity of zinc and possible role in COVID-19.The British journal of nutrition · 2022Review
- Potential health benefits of zinc supplementation for the management of COVID-19 pandemic.Journal of food biochemistry · 2021Review
- Cecal Slurry Injection in Neonatal and Adult Mice.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Article
- Zinc inhibits lethal inflammatory shock by preventing microbe-induced interferon signature in intestinal epithelium.EMBO molecular medicine · 2020Article
- Proprotein Convertase Subtilisin/Kexin Type 9 Loss-of-Function Is Detrimental to the Juvenile Host With Septic Shock.Critical care medicine · 2020Article
- Zinc and respiratory tract infections: Perspectives for COVID‑19 (Review).International journal of molecular medicine · 2020Review
- Exploring Clinically-Relevant Experimental Models of Neonatal Shock and Necrotizing Enterocolitis.Shock (Augusta, Ga.) · 2020Review
- Zinc and Sepsis.Nutrients · 2018Review
- Nutritional Modulation of Immune Function: Analysis of Evidence, Mechanisms, and Clinical Relevance.Frontiers in immunology · 2018Review
- The Potential Impact of Zinc Supplementation on COVID-19 Pathogenesis.Frontiers in immunologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Children with severe sepsis are known to have altered zinc homeostasis and decreased circulating zinc levels, suggesting a role for zinc supplementation to improve outcomes. We tested the hypothesis that zinc supplementation would improve survival in a juvenile model of polymicrobial sepsis. Juvenile (13-14-d-old) C57BL/6 mice were treated with 10 mg/kg of zinc via i.p. injections (or vehicle) for 3 d prior to induction of polymicrobial sepsis via i.p. cecal slurry injections. Survival after sepsis was followed for 3 d, and bacterial clearance, ex vivo phagocytosis, systemic inflammatory markers and neutrophil extracellular trap (NET) formation were quantified. We found a significant survival benefit and decreased bacterial burden among zinc supplemented mice when compared with the control group. Zinc supplementation also resulted in enhanced phagocytic activity, greater neutrophil recruitment in the peritoneal cavity and NET formation, suggesting a possible mechanism for improved bacterial clearance and survival. We also noted decreased serum cytokine levels and decreased myeloperoxidase activity in lung tissue following zinc supplementation, suggesting attenuation of the systemic inflammatory response. In conclusion, zinc supplementation improves bacterial clearance, and hence survival, in juvenile mice with polymicrobial sepsis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.