Evidence map›Paper›PMID 27821621›Full record

ArticleThe Biochemical journal2017

Dopamine D1A directly interacts with otoferlin synaptic pathway proteins: Ca2+ and phosphorylation underlie an NSF-to-AP2mu1 molecular switch.

Dakshnamurthy Selvakumar, Marian J Drescher, Nathan A Deckard, Neeliyath A Ramakrishnan, Barbara J Morley, Dennis G Drescher

Open access · bronzeAbstract read
In one paragraph

Article in The Biochemical journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Otoferlin as a multirole CaFrontiers in cellular neuroscience · 2023
    Review
  4. Article
  5. Article
  6. Imaging EGFR and HER3 throughScientific reports · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Dakshnamurthy SelvakumarLaboratory of Bio-otology, Department of Otolaryngology, Wayne State University School of Medicine, Detroit, MI 48201, U.S.A.
Marian J DrescherLaboratory of Bio-otology, Department of Otolaryngology, Wayne State University School of Medicine, Detroit, MI 48201, U.S.A. mdresche@med.wayne.edu.
Nathan A DeckardLaboratory of Bio-otology, Department of Otolaryngology, Wayne State University School of Medicine, Detroit, MI 48201, U.S.A.
Neeliyath A RamakrishnanLaboratory of Bio-otology, Department of Otolaryngology, Wayne State University School of Medicine, Detroit, MI 48201, U.S.A.
Barbara J MorleyBoys Town National Research Hospital, Omaha, Nebraska 68131, U.S.A.
Dennis G DrescherLaboratory of Bio-otology, Department of Otolaryngology, Wayne State University School of Medicine, Detroit, MI 48201, U.S.A.
Wayne State University · USBoys Town National Research Hospital · US

Funding

Tumor Biology and Microenvironment (Program 1)P30CA022453 · NCI · WAYNE STATE UNIVERSITY · PI Julie Lynn Boerner · 1985 to 2026
$68.4M
IDENTIFICATION OF ACOUSTICO-LATERALIS TRANSMITTERSR01DC000156 · NIDCD · WAYNE STATE UNIVERSITY · PI DRESCHER, DENNIS G · 1989 to 2013
$3.9M
ADENYLYL CYCLASE SIGNALING IN EAR SENSORY EPITHELIAR01DC004076 · NIDCD · WAYNE STATE UNIVERSITY · PI DRESCHER, MARIAN JEAN · 1999 to 2009
$1.8M
NCI NIH HHS P30 CA022453NIDCD NIH HHS R01 DC000156NIDCD NIH HHS R01 DC004076
6 · The paper itself

Abstract

Dopamine receptors regulate exocytosis via protein-protein interactions (PPIs) as well as via adenylyl cyclase transduction pathways. Evidence has been obtained for PPIs in inner ear hair cells coupling D1A to soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein receptor (SNARE)-related proteins snapin, otoferlin, N-ethylmaleimide-sensitive factor (NSF), and adaptor-related protein complex 2, mu 1 (AP2mu1), dependent on [Ca

Indexed as

Fish ProteinsN-Ethylmaleimide-Sensitive ProteinsReceptors, Dopamine D1SynapsesTroutAnimalsCalcium SignalingHair Cells, VestibularMiceRatsSNARE Proteinsdopamine D1A receptorFish ProteinsN-Ethylmaleimide-Sensitive ProteinsReceptors, Dopamine D1SNARE ProteinsAP2mu1dopamine D1Ahair cellNSFotoferlin synaptic complexsurface plasmon resonance

Identifiers

PMID27821621
PMCPMC6310132
OpenAlexW2557181013

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.