Evidence map›Paper›PMID 27821605›Full record

Trial reportClinical cancer research : an official journal of the American Association for Cancer Research2017

A Phase I/II Multicenter Study of Single-Agent Foretinib as First-Line Therapy in Patients with Advanced Hepatocellular Carcinoma.

Thomas C C Yau, Riccardo Lencioni, Wattana Sukeepaisarnjaroen, Yee Chao, Chia-Jui Yen, Wirote Lausoontornsiri, Pei-Jer Chen, Theeranun Sanpajit, Aaron Camp, Donna S Cox and 8 more

Abstract readClinical Trial, Phase IClinical Trial, Phase IIMulticenter Study
In one paragraph

Trial report in Clinical cancer research : an official journal of the American Association for Cancer Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. EMT and cancer: what clinicians should know.Nature reviews. Clinical oncology · 2025
    Review
  7. Review
  8. Article
  9. Bioactive Products Targeting C-Met As Potential Antitumour Drugs.Anti-cancer agents in medicinal chemistry · 2025
    Review
  10. Article
  11. EphA2 in Cancer: Molecular Complexity and Therapeutic Opportunities.International journal of molecular sciences · 2024
    Review
  12. The MET Oncogene: An Update on Targeting Strategies.Pharmaceuticals (Basel, Switzerland) · 2024
    Review
  13. Therapeutic advances of targeting receptor tyrosine kinases in cancer.Signal transduction and targeted therapy · 2024
    Review
  14. MERTK Inhibition as a Targeted Novel Cancer Therapy.International journal of molecular sciences · 2024
    Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Thomas C C YauDepartment of Medicine, The University of Hong Kong, Hong Kong, China.
Riccardo LencioniDivision of Diagnostic Imaging and Intervention, University of Pisa, Pisa, Italy.
Wattana SukeepaisarnjaroenFaculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Yee ChaoCancer Center, Taipei Veterans General Hospital, Taipei, Taiwan.
Chia-Jui YenInternal Medicine, National Cheng University Hospital, Tainan, Taiwan.
Wirote LausoontornsiriClinical Cancer Research Center, National Cancer Institute of Thailand, Bangkok, Thailand.
Pei-Jer ChenGraduate Institute of Clinical Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Theeranun SanpajitDivision of Digestive and Liver Diseases, Phramongkutklao Hospital, Bangkok, Thailand.
Aaron CampPPD, Inc., Austin, Texas.
Donna S CoxGlaxoSmithKline, King of Prussia, Pennsylvania.
Robert C GagnonGlaxoSmithKline, Collegeville, Pennsylvania.
Yuan LiuGlaxoSmithKline, Collegeville, Pennsylvania.
Kristen E RaffenspergerUrologic Oncology Branch, National Cancer Institute, NIH, Bethesda, Maryland.
Diptee A KulkarniGlaxoSmithKline, King of Prussia, Pennsylvania.
Howard KallenderGlaxoSmithKline, Collegeville, Pennsylvania.
Lone Harild OttesenGlaxoSmithKline, Uxbridge, United Kingdom.
Ronnie T P PoonDepartment of Surgery, The University of Hong Kong, Hong Kong, China.
Donald P BottaroUrologic Oncology Branch, National Cancer Institute, NIH, Bethesda, Maryland. dbottaro@helix.nih.gov.

Funding

Oncogenic Met Signaling in Urologic MalignanciesZIABC011124 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI BOTTARO, DONALD · 2009 to 2021
$5.8M
Oncogenic Met Signaling in Urologic MalignanciesZ01BC011124 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI BOTTARO, DONALD · 2008 to 2008
$242k
Intramural NIH HHS Z01 BC011124
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdultAgedAnilidesAxl Receptor Tyrosine KinaseBiomarkers, PharmacologicalCarcinoma, HepatocellularFemaleHumansInterleukin-6Interleukin-8Liver NeoplasmsMaleMaximum Tolerated DoseMiddle AgedProtein-Tyrosine KinasesProto-Oncogene ProteinsAnilidesAXL protein, humanAxl Receptor Tyrosine KinaseBiomarkers, PharmacologicalCXCL8 protein, humanGSK 1363089IL6 protein, humanInterleukin-6Interleukin-8KDR protein, humanMET protein, humanProtein-Tyrosine KinasesProto-Oncogene ProteinsProto-Oncogene Proteins c-metQuinolinesReceptor Protein-Tyrosine KinasesReceptor, TIE-2RON proteinROS1 protein, humanVascular Endothelial Growth Factor Receptor-2

Identifiers

PMID27821605
PMCPMC5420486

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.