Evidence map›Paper›PMID 27821594›Full record

ArticleThe Journal of biological chemistry2016

General Anesthetic Binding Sites in Human α4β3δ γ-Aminobutyric Acid Type A Receptors (GABAARs).

David C Chiara, Youssef Jounaidi, Xiaojuan Zhou, Pavel Y Savechenkov, Karol S Bruzik, Keith W Miller, Jonathan B Cohen

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. GABAJournal, genetic engineering & biotechnology · 2021
    Review
  4. Binding site location on GABABritish journal of pharmacology · 2019
    Article
  5. Etomidate Effects on Desensitization and Deactivation ofThe Journal of pharmacology and experimental therapeutics · 2019
    Article
  6. Comparison of αβδ and αβγ GABAPharmacological research · 2018
    Review
  7. GABANeuropharmacology · 2018
    Review
  8. Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

David C ChiaraFrom the Departments of Neurobiology and.
Youssef Jounaidithe Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, and.
Xiaojuan Zhouthe Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, and.
Pavel Y Savechenkovthe Department of Medicinal Chemistry and Pharmacognosy, University of Illinois, Chicago, Illinois 60612.
Karol S Bruzikthe Department of Medicinal Chemistry and Pharmacognosy, University of Illinois, Chicago, Illinois 60612.
Keith W Millerthe Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, and.
Jonathan B CohenFrom the Departments of Neurobiology and jonathan_cohen@hms.harvard.edu.
Massachusetts General Hospital · USInstitute of Neurobiology · BGUniversity of Illinois Chicago · US

Funding

Synthetic Chemistry CoreP01GM058448 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI MILLER, KEITH W · 1999 to 2018
$33.6M
NIGMS NIH HHS P01 GM058448
6 · The paper itself

Abstract

Extrasynaptic γ-aminobutyric acid type A receptors (GABA

Indexed as

BarbituratesBinding SitesHEK293 CellsHumansProtein Structure, QuaternaryReceptors, GABABarbituratesbarbituric acidReceptors, GABAallosteric regulationanestheticCys-loop receptorGABA receptorphotoaffinity labeling

Identifiers

PMID27821594
PMCPMC5159512
OpenAlexW2556514773

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.