ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2016
Embryonic chirality and the evolution of spiralian left-right asymmetries.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 37 citations in OpenAlex.
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- Actin polymerisation and crosslinking drive left-right asymmetry in single cell and cell collectives.Nature communications · 2023Article
- A Small Change With a Twist Ending: A Single Residue in EGF-CFC Drives Bilaterian Asymmetry.Molecular biology and evolution · 2023Article
- Combined effect of cell geometry and polarity domains determines the orientation of unequal division.eLife · 2021Article
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- Molecular patterning during the development ofEvoDevo · 2019Article
- Chirality provides a direct fitness advantage and facilitates intermixing in cellular aggregates.PLoS computational biology · 2018Article
- The Molecular Differentiation of Anatomically Paired Left and Right Mantles of the Pacific Oyster Crassostrea gigas.Marine biotechnology (New York, N.Y.) · 2018Article
- Article
- Cerberus-Nodal-Lefty-Pitx signaling cascade controls leftProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Introduction to provocative questions in left-right asymmetry.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The group Spiralia includes species with one of the most significant cases of left-right asymmetries in animals: the coiling of the shell of gastropod molluscs (snails). In this animal group, an early event of embryonic chirality controlled by cytoskeleton dynamics and the subsequent differential activation of the genes nodal and Pitx determine the left-right axis of snails, and thus the direction of coiling of the shell. Despite progressive advances in our understanding of left-right axis specification in molluscs, little is known about left-right development in other spiralian taxa. Here, we identify and characterize the expression of nodal and Pitx orthologues in three different spiralian animals-the brachiopod Novocrania anomala, the annelid Owenia fusiformis and the nemertean Lineus ruber-and demonstrate embryonic chirality in the biradial-cleaving spiralian embryo of the bryozoan Membranipora membranacea We show asymmetric expression of nodal and Pitx in the brachiopod and annelid, respectively, and symmetric expression of Pitx in the nemertean. Our findings indicate that early embryonic chirality is widespread and independent of the cleavage programme in the Spiralia. Additionally, our study illuminates the evolution of nodal and Pitx signalling by demonstrating embryonic asymmetric expression in lineages without obvious adult left-right asymmetries.This article is part of the themed issue 'Provocative questions in left-right asymmetry'.
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