ArticleMolecular and cellular biology2017
Functional Roles of Acetylated Histone Marks at Mouse Meiotic Recombination Hot Spots.
Article in Molecular and cellular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
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- Testis-specific H2B.W1 disrupts nucleosome integrity by reducing DNA-histone interactions.Nucleic acids research · 2024Article
- Transcriptome profiling of histone writers/erasers enzymes across spermatogenesis, mature sperm and pre-cleavage embryo: Implications in paternal epigenome transitions and inheritance mechanisms.Frontiers in cell and developmental biology · 2023Article
- The Essential Function of SETDB1 in Homologous Chromosome Pairing and Synapsis during Meiosis.Cell reports · 2021Article
- Editorial: Meiosis: From Molecular Basis to Medicine.Frontiers in cell and developmental biology · 2021Article
- Histone Post-Translational Modifications and CircRNAs in Mouse and Human Spermatozoa: Potential Epigenetic Marks to Assess Human Sperm Quality.Journal of clinical medicine · 2020Review
- Cell-type-specific genomics reveals histone modification dynamics in mammalian meiosis.Nature communications · 2019Article
- Meiosis in the scorpionBiology open · 2019Article
- A Co-Expression Network in Hexaploid Wheat Reveals Mostly Balanced Expression and Lack of Significant Gene Loss of Homeologous Meiotic Genes Upon Polyploidization.Frontiers in plant science · 2019Article
- LDSplitDB: a database for studies of meiotic recombination hotspots in MHC using human genomic data.BMC medical genomics · 2018Article
- Transient reduction of DNA methylation at the onset of meiosis in male mice.Epigenetics & chromatin · 2018Article
- Where to Cross Over? Defining Crossover Sites in Plants.Frontiers in genetics · 2018Review
- Article
- Repeated losses of PRDM9-directed recombination despite the conservation of PRDM9 across vertebrates.eLife · 2017Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
Meiotic recombination initiates following the formation of DNA double-strand breaks (DSBs) by the Spo11 endonuclease early in prophase I, at discrete regions in the genome coined "hot spots." In mammals, meiotic DSB site selection is directed in part by sequence-specific binding of PRDM9, a polymorphic histone H3 (H3K4Me3) methyltransferase. However, other chromatin features needed for meiotic hot spot specification are largely unknown. Here we show that the recombinogenic cores of active hot spots in mice harbor several histone H3 and H4 acetylation and methylation marks that are typical of open, active chromatin. Further, deposition of these open chromatin-associated histone marks is dynamic and is manifest at spermatogonia and/or pre-leptotene-stage cells, which facilitates PRDM9 binding and access for Spo11 to direct the formation of DSBs, which are initiated at the leptotene stage. Importantly, manipulating histone acetylase and deacetylase activities established that histone acetylation marks are necessary for both hot spot activity and crossover resolution. We conclude that there are functional roles for histone acetylation marks at mammalian meiotic recombination hot spots.
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