ArticleJournal of the American Heart Association2016
Long-Term Visit-to-Visit Blood Pressure Variability and Renal Function Decline in Patients With Hypertension Over 15 Years.
Article in Journal of the American Heart Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04342468 (Relationship of Blood Pressure Variability and Cardiovascular Disease Events Among Patients With Hypertension), which is not on this map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Relationship of Blood Pressure Variability and Cardiovascular Disease Events Among Patients With Hypertension
Who cites it
28 citing papers in PubMed.
- Variability in home blood pressure and its association with renal function and pulse pressure in patients with treated hypertension in primary care.Journal of human hypertension · 2024Trial
- Long-Term Blood Pressure Variability and Kidney Function in Participants of the ASPREE Trial.American journal of hypertension · 2022Trial
- Asian expert consensus on high-quality hypertension management.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Review
- Sex modifies the association between blood pressure variability and lung function decline among population over 45 years old: a pooled analysis of two national cohorts.Journal of thoracic disease · 2026Article
- Baseline Human Metabolic Profiling and Risk of Death from COVID-19: Conceptualization of Multivariate Prediction Model Development via Retrospective Database Analysis in the United States Department of Veterans Affairs.Journal of clinical medicine · 2026Article
- Clinical Significance of Mean and Day-to-Day Variability of Home Blood Pressure in Chronic Kidney Disease: A Retrospective Cohort Study.JMA journal · 2026Article
- High intradialysis diastolic blood pressure variability is an independent predictor of all-cause mortality.Annals of medicine · 2025Article
- Socioeconomic disparities in physiological dysregulation: a longitudinal mediation analysis of cardiometabolic multimorbidity among middle-aged and elderly Chinese.BMC public health · 2025Observational
- Blood pressure variability: a review.Journal of hypertension · 2025Review
- Physiological measures variability and risks of heart disease and stroke: evidence from three cohort studies.BMC medicine · 2024Article
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- Relationship between visit-to-visit blood pressure variability and depressive mood in Korean primary care patients.BMC primary care · 2024Article
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- Article
- Association between gestational visit-to-visit blood pressure variability and adverse neonatal outcomes.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
- Associations of Long-Term Visit-to-Visit Blood Pressure Variability With Subclinical Kidney Damage and Albuminuria in Adulthood: a 30-Year Prospective Cohort Study.Hypertension (Dallas, Tex. : 1979) · 2022Article
- Long-term predialysis blood pressure variability and outcomes in hemodialysis patients.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
- Burden of chronic kidney disease and rapid decline in renal function among adults attending a hospital-based diabetes center in Northern Europe.BMJ open diabetes research & care · 2021Article
- Trajectory of renal function change and kidney injury after percutaneous coronary intervention in patients with stable coronary artery disease.Heart and vessels · 2021Article
- Comparison of day-to-day blood pressure variability in hypertensive patients with type 2 diabetes mellitus to those without diabetes: Asia BP@Home Study.Journal of clinical hypertension (Greenwich, Conn.) · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVisit-to-visit variability of systolic blood pressure (SBP) has been shown to contribute to cardiovascular events and all-cause mortality. However, little is known about its long-term effect on renal function. We aim to examine the relationship between visit-to-visit blood pressure variability (BPV) and decline in renal function in patients with hypertension and to determine the level of systolic BPV that is associated with significant renal function decline. METHODS AND
resultsThis is a 15-year retrospective cohort study of 825 hypertensive patients. Blood pressure readings every 3 months were retrieved from the 15 years of clinic visits. We used SD and coefficient of variation as a measure of systolic BPV. Serum creatinine was captured and estimated glomerular filtration rate was calculated at baseline, 5, 10, and 15 years. The mean SD of SBP was 14.2±3.1 mm Hg and coefficient of variation of SBP was 10.2±2%. Mean for estimated glomerular filtration rate slope was -1.0±1.5 mL/min per 1.73 m
conclusionsLong-term visit-to-visit variability of SBP is an independent determinant of renal deterioration in patients with hypertension. Hence, every effort should be made to reduce BPV in order to slow down the decline of renal function.
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