ArticlePsychiatry research2016
Pupillary response abnormalities in depressive disorders.
Article in Psychiatry research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07474974 (Illuminating Depression), which is not on this map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Illuminating Depression: ipRGC as a Potential Biomarker for Predicting Transcranial Magnetic Stimulation Treatment Response in Major Depressive Disorder
Who cites it
24 citing papers in PubMed, 42 citations in OpenAlex.
- The Ottawa sunglasses at night study: A randomized controlled trial of blue-blocking glasses for mania.Journal of affective disorders · 2026Trial
- Can the Pupillary Light Reflex and Pupillary Unrest Be Used as Biomarkers of Parkinson's Disease? A Systematic Review and Meta-Analysis.Diagnostics (Basel, Switzerland) · 2025Review
- Pathophysiological Models of Hypersomnolence Associated With Depression.Biological psychiatry global open science · 2025Review
- Multiple factors contribute to pupillary light reflex: implications for screening of traumatic brain injury in military service members.Clinical neurophysiology practice · 2025Article
- Observational
- Altered pupil light and darkness reflex and eye-blink responses in late-life depression.BMC geriatrics · 2024Article
- A Review of the Use of Gaze and Pupil Metrics to Assess Mental Workload in Gamified and Simulated Sensorimotor Tasks.Sensors (Basel, Switzerland) · 2024Review
- Assessing hypo-arousal during reward anticipation with pupillometry in patients with major depressive disorder: replication and correlations with anhedonia.Scientific reports · 2024Article
- The impact of Alzheimer's disease risk factors on the pupillary light response.Frontiers in neuroscience · 2023Review
- BLUES - stabilizing mood and sleep with blue blocking eyewear in bipolar disorder - a randomized controlled trial study protocol.Annals of medicine · 2023Article
- Blunted pupil light reflex is associated with negative symptoms and working memory in individuals with schizophrenia.Schizophrenia research · 2022Article
- The melanopsin-mediated pupil response is reduced in idiopathic hypersomnia with long sleep time.Scientific reports · 2022Article
- Treatment of depression in the elderly with repetitive transcranial magnetic stimulation using theta-burst stimulation: Study protocol for a randomized, double-blind, controlled trial.Frontiers in human neuroscience · 2022Article
- Alterations of color vision and pupillary light responses in age-related macular degeneration.Frontiers in aging neuroscience · 2022Article
- The pupillary light reflex (PLR) as a marker for the ability to work or drive - a feasibility study.Journal of occupational medicine and toxicology (London, England) · 2021Article
- Quantitative Infrared Pupillometry in Nonconvulsive Status Epilepticus.Neurocritical care · 2021Observational
- Melanopsin-driven pupil response in summer and winter in unipolar seasonal affective disorder.Journal of affective disorders · 2021Article
- Melanopsin-mediated pupillary responses in bipolar disorder-a cross-sectional pupillometric investigation.International journal of bipolar disorders · 2021Article
- Pupillary Responses for Cognitive Load Measurement to Classify Difficulty Levels in an Educational Video Game: Empirical Study.JMIR serious games · 2021Article
- Endogenous Opioid Signaling in the Mouse Retina Modulates Pupillary Light Reflex.International journal of molecular sciences · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Depressive disorders lack objective physiological measurements to characterize the affected population and facilitate study of relevant mechanisms. The melanopsin-mediated light signaling pathway may contribute to seasonal variation and can be measured non-invasively by pupillometry. We prospectively studied changes in melanopsin-mediated pupillary constriction in 19 participants with major depressive disorder (MDD) and 10 control across the summer and winter solstices. The melanopsin-mediated response, as measured by the pupil's sustained constriction six s after a high intensity blue light stimulus, was marginally attenuated in those with MDD relative to controls (p=0.071). The participants with MDD unexpectedly showed a significantly reduced transient pupillary response to low intensity red (p=0.011) and blue light (p=0.013), but not high intensity red and blue light. Sustained pupillary constriction in response to high intensity blue light was more pronounced with increasing daylight hours (p=0.037) and was more strongly related to objectively measured versus estimated light exposure. Melanopsin-mediated impairments in pupil response may serve as a biological marker for vulnerability to depression in low light conditions. Assessment of these and other responses to light stimuli, such as response to low intensity light, may be useful for the study of the neurobiology of MDD and related mood disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.