ArticleEpidemiology and infection2017
Characterizing the risk of respiratory syncytial virus in infants with older siblings: a population-based birth cohort study.
Article in Epidemiology and infection, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Environmental lead exposure and clinical infectious respiratory disease in a sample of urban and disadvantaged children.Journal of exposure science & environmental epidemiology · 2026Article
- Article
- Urban environment and RSV: a retrospective observational study of neighbourhood factors associated with the risk of severe disease in the infant population of a metropolitan area, Lyon, France.BMC public health · 2025Observational
- Respiratory syncytial virus vaccines for toddlers and school-aged children: a pressing necessity for global health.Frontiers in pediatrics · 2025Article
- Burden of respiratory syncytial virus disease in infants and the potential value of maternal immunization in Greece.Frontiers in public health · 2025Article
- Resurgence of Respiratory Syncytial Virus in the Summer of 2021 in Denmark-a Large out-of-season Epidemic Affecting Older Children.Open forum infectious diseases · 2024Article
- Are we ready to face the next wave of RSV surge after the COVID-19 Omicron pandemic in China?Frontiers in cellular and infection microbiology · 2023Article
- RSV disease in infants and young children: Can we see a brighter future?Human vaccines & immunotherapeutics · 2022Article
- Respiratory Syncytial Virus Incidence and Severity in a Community-Based Prospective Cohort of Children Aged 0-14 Years.Open forum infectious diseases · 2022Article
- Influenza and respiratory syncytial virus during the COVID-19 pandemic: Time for a new paradigm?Pediatric pulmonology · 2022Article
- RSV Prevention in All Infants: Which Is the Most Preferable Strategy?Frontiers in immunology · 2022Review
- Risk of Transmission and Viral Shedding From the Time of Infection for Respiratory Syncytial Virus in Households.American journal of epidemiology · 2021Article
- Observational
- Multiple Respiratory Syncytial Virus Introductions Into a Neonatal Intensive Care Unit.Journal of the Pediatric Infectious Diseases Society · 2021Article
- Modelling the household-level impact of a maternal respiratory syncytial virus (RSV) vaccine in a high-income setting.BMC medicine · 2020Article
- Model-based estimates of transmission of respiratory syncytial virus within households.Epidemics · 2019Article
- The contribution of child, family and health service factors to respiratory syncytial virus (RSV) hospital admissions in the first 3 years of life: birth cohort study in Scotland, 2009 to 2015.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2019Article
- Meteorological factors and respiratory syncytial virus seasonality in subtropical Australia.Epidemiology and infection · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
From a population-based birth cohort of 245 249 children born in Western Australia during 1996-2005, we used linkage of laboratory and birth record datasets to obtain data including all respiratory syncytial virus (RSV) detections during infancy from a subcohort of 87 981 singleton children born in the Perth metropolitan area from 2000 to 2004. Using log binomial regression, we found that the risk of infant RSV detection increases with the number of older siblings, with those having ⩾3 older siblings experiencing almost three times the risk (relative risk 2·83, 95% confidence interval 2·46-3·26) of firstborn children. We estimate that 45% of the RSV detections in our subcohort were attributable to infection from an older sibling. The sibling effect was significantly higher for those infants who were younger during the season of peak risk (winter) than those who were older. Although older siblings were present in our cohort, they had very few RSV detections which could be temporally linked to an infant's infection. We conclude that RSV infection in older children leads to less severe symptoms but is nevertheless an important source of infant infection. Our results lend support to a vaccination strategy which includes family members in order to provide maximum protection for newborn babies.
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