ArticleBMC microbiology2016
CP40 from Corynebacterium pseudotuberculosis is an endo-β-N-acetylglucosaminidase.
Article in BMC microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- The mechanistic basis for interprotomer deglycosylation of antibodies by corynebacterial IgG-specific endoglycosidases.Nature communications · 2025Article
- Oral fluid as a material for serological diagnostics of caseous lymphadenitis in goats.Scientific reports · 2025Article
- Immunization of mice and goats with Corynebacterium pseudotuberculosis-derived rPTS, rRBN and rCP40 recombinant proteins.World journal of microbiology & biotechnology · 2025Article
- Article
- Ovine and Caprine Strains ofMicroorganisms · 2024Article
- Immunomodulating Enzymes fromMicroorganisms · 2024Review
- Bioinformatic Approach of B and T Cell Epitopes of PLD and CP40 Proteins ofInternational journal of molecular sciences · 2023Article
- Bacterial Chitinases and Their Role in Human Infection.Infection and immunity · 2023Review
- A panel of recombinant proteins for the serodiagnosis of caseous lymphadenitis in goats and sheep.Microbial biotechnology · 2019Article
- Streptococcal Endo-β-Frontiers in immunology · 2018Article
- Immune-Informatic Analysis and Design of Peptide Vaccine From Multi-epitopes AgainstBioinformatics and biology insights · 2018Article
- Insight of GenusFrontiers in microbiology · 2017Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundC. pseudotuberculosis is an important animal pathogen that causes substantial economical loss in sheep and goat farming. Zoonotic infections in humans are rare, but when they occur they are often severe and difficult to treat. One of the most studied proteins from this bacterium, the secreted protein CP40 is being developed as a promising vaccine candidate and has been characterized as a serine protease. In this study we have investigated if CP40 is an endoglycosidase rather than a protease.
resultsCP40 does not show any protease activity and contains an EndoS-like family 18 of glycoside hydrolase (chitinase) motif. It hydrolyzes biantennary glycans on both human and ovine IgGs. CP40 is not a general chitinase and cannot hydrolyze bisecting GlcNAc.
conclusionTaken together we present solid evidence for re-annotating CP40 as an EndoS-like endoglycosidase. Redefining the activity of this enzyme will facilitate subsequent studies that could give further insight into immune evasion mechanisms underlying corynebacterial infections in animals and humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.