ArticleBMC genomics2016
Babesia microti from humans and ticks hold a genomic signature of strong population structure in the United States.
Article in BMC genomics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Development of Multiplex Assays for the Identification of ZoonoticPathogens (Basel, Switzerland) · 2024Article
- Human Babesia odocoilei and Bartonella spp. co-infections in the Americas.Parasites & vectors · 2024Article
- Identification ofInfection and immunity · 2024Article
- Prevalence and molecular detection of Babesia microti in rodents in Southeastern Shanxi, China.PloS one · 2024Article
- The impact of ABO and RhD blood types on Babesia microti infection.PLoS neglected tropical diseases · 2023Article
- Detection of multiple tick-borne pathogens inCurrent research in parasitology & vector-borne diseases · 2023Article
- Epitope profiling of monoclonal antibodies to the immunodominant antigen BmGPI12 of the human pathogenFrontiers in cellular and infection microbiology · 2022Article
- The Global Emergence of Human Babesiosis.Pathogens (Basel, Switzerland) · 2021Review
- Circulation ofPathogens (Basel, Switzerland) · 2021Article
- Review
- The Babesia observational antibody (BAOBAB) study: A cross-sectional evaluation of Babesia in two communities in Kilosa district, Tanzania.PLoS neglected tropical diseases · 2019Article
- BmGPAC, an Antigen Capture Assay for Detection of Active Babesia microti Infection.Journal of clinical microbiology · 2018Article
- Transplacental transmission of tick-borne Babesia microti in its natural host Peromyscus leucopus.Parasites & vectors · 2018Article
- Case report of the patient source of the Babesia microti R1 reference strain and implications for travelers.Journal of travel medicine · 2018Article
- Genomic insights into the ancient spread of Lyme disease across North America.Nature ecology & evolution · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
backgroundBabesia microti is an emerging tick-borne apicomplexan parasite with increasing geographic range and incidence in the United States. The rapid expansion of B. microti into its current distribution in the northeastern USA has been due to the range expansion of the tick vector, Ixodes scapularis, upon which the causative agent is dependent for transmission to humans.
resultsTo reconstruct the history of B. microti in the continental USA and clarify the evolutionary origin of human strains, we used multiplexed hybrid capture of 25 B. microti isolates obtained from I. scapularis and human blood. Despite low genomic variation compared with other Apicomplexa, B. microti was strongly structured into three highly differentiated genetic clusters in the northeastern USA. Bayesian analyses of the apicoplast genomes suggest that the origin of the current diversity of B. microti in northeastern USA dates back 46 thousand years with a signature of recent population expansion in the last 1000 years. Human-derived samples belonged to two rarely intermixing clusters, raising the possibility of highly divergent infectious phenotypes in humans.
conclusionsOur results validate the multiplexed hybrid capture strategy for characterizing genome-wide diversity and relatedness of B. microti from ticks and humans. We find strong population structure in B. microti samples from the Northeast indicating potential barriers to gene flow.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.