ArticleInvestigative ophthalmology & visual science2016
Longitudinal Evaluation of Eye Misalignment and Eye Movements Following Surgical Correction of Strabismus in Monkeys.
Article in Investigative ophthalmology & visual science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- Quantitative Assessment of Fixational Disparity Using a Binocular Eye-Tracking Technique in Children with Strabismus.Journal of eye movement research · 2025Article
- Effects of Short-Term Treatment of Rabbit Extraocular Muscle With Ciliary Neurotrophic Factor.Investigative ophthalmology & visual science · 2024Article
- Fixation eye movement abnormalities and stereopsis recovery following strabismus repair.Scientific reports · 2021Article
- Effect of Fibroblast Growth Factor 2 on Extraocular Muscle Structure and Function.Investigative ophthalmology & visual science · 2021Article
- Fixation stability after surgical treatment of strabismus and biofeedback fixation training in amblyopic eyes.BMC ophthalmology · 2021Article
- Eye alignment changes caused by sustained GDNF treatment of an extraocular muscle in infant non-human primates.Scientific reports · 2020Article
- Morphological Differences in the Inferior Oblique Muscles from Subjects with Over-elevation in Adduction.Investigative ophthalmology & visual science · 2020Article
- Horizontal Saccadic Velocity in Patients with Exotropia before and after Unilateral Resection and Recession Surgery.Journal of ophthalmology · 2019Article
- Neural Plasticity Following Surgical Correction of Strabismus in Monkeys.Investigative ophthalmology & visual science · 2018Article
- Visualizing Neuronal Adaptation Over Time After Treatment of Strabismus.Investigative ophthalmology & visual science · 2018Article
- Changing muscle function with sustained glial derived neurotrophic factor treatment of rabbit extraocular muscle.PloS one · 2018Article
- Nonhuman Primate Studies to Advance Vision Science and Prevent Blindness.ILAR journal · 2017Review
- Childhood Onset Strabismus: A Neurotrophic Factor Hypothesis.Journal of binocular vision and ocular motilityArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
purposeStrabismus correction surgery is well documented in both the literature and practice with varying levels of success and permanence. Our goal was to characterize longitudinal changes in eye alignment and eye movements following strabismus correction surgery in a monkey model for developmental strabismus.
methodsWe studied two juvenile rhesus monkeys with exotropia previously induced via an optical prism-rearing paradigm in infancy. Eye misalignment was corrected via a resection-recession surgery of the horizontal rectus muscles of one eye. Binocular search coils were used to collect eye movement data during smooth-pursuit, saccades, and fixation tasks before surgical treatment, immediately after surgery, and through 6 months after treatment.
resultsBoth animals showed an immediate ∼70% reduction in misalignment as a consequence of surgery that regressed to a 20%-40% improvement by 6 months after treatment. Significant changes were observed in saccade and smooth-pursuit gain of the nonviewing eye after surgery, which also reverted to presurgical values by 6 months. A temporary improvement in fixation stability of the nonviewing eye was observed after surgery; naso-temporal (N/T) asymmetry of monocular smooth-pursuit remained unchanged.
conclusionsSurgical realignment is followed by plastic changes that often lead to reversal of surgery effects. Immediate improvement in misalignment and changes in eye movement gains are likely a result of contractility changes at the level of the extraocular muscle, whereas longer-term effects are likely a combination of neural and muscle adaptation.
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