ArticlePloS one2016
Preclinical Immunomodulation by the Probiotic Bifidobacterium breve M-16V in Early Life.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Probiotic supplementation is associated with higher faecal secretory IgA (sIgA) in healthy full-term infants: a systematic review and meta-analysis.Pediatric research · 2026Pooled it
- Targeting intestinal microbiota withClinical and experimental vaccine research · 2026Article
- Early Inoculation of a Multi-Species Probiotic in Piglets-Impacts on the Gut Microbiome and Immune Responses.Microorganisms · 2025Article
- Maternal Synbiotic Supplementation withNutrients · 2024Article
- Impact of maternalFrontiers in immunology · 2024Article
- Article
- Effect of the Microbiome on Intestinal Innate Immune Development in Early Life and the Potential Strategy of Early Intervention.Frontiers in immunology · 2022Review
- Role of Bifidobacteria on Infant Health.Microorganisms · 2021Review
- Review
- The Complex Interactions Between Rotavirus and the Gut Microbiota.Frontiers in cellular and infection microbiology · 2020Review
- Review
- Effects ofWorld journal of gastroenterology · 2019Article
- A Preterm Rat Model for Immunonutritional Studies.Nutrients · 2019Article
- Influence of Leptin and Adiponectin Supplementation on Intraepithelial Lymphocyte and Microbiota Composition in Suckling Rats.Frontiers in immunology · 2019Article
- Immunomodulatory and Prebiotic Effects of 2'-Fucosyllactose in Suckling Rats.Frontiers in immunology · 2019Article
- Integral Roles for Integrins in γδ T Cell Function.Frontiers in immunology · 2018Review
- Preventive Effect of a Synbiotic Combination of Galacto- and Fructooligosaccharides Mixture WithFrontiers in immunology · 2018Article
- A Specific Mixture of Fructo-Oligosaccharides andFrontiers in immunology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to investigate the effect of supplementation with the probiotic Bifidobacterium breve M-16V on the maturation of the intestinal and circulating immune system during suckling. In order to achieve this purpose, neonatal Lewis rats were supplemented with the probiotic strain from the 6th to the 18th day of life. The animals were weighed during the study, and faecal samples were obtained and evaluated daily. On day 19, rats were euthanized and intestinal wash samples, mesenteric lymph node (MLN) cells, splenocytes and intraepithelial lymphocytes (IEL) were obtained. The probiotic supplementation in early life did not modify the growth curve and did not enhance the systemic immune maturation. However, it increased the proportion of cells bearing TLR4 in the MLN and IEL, and enhanced the percentage of the integrin αEβ7+ and CD62L+ cells in the MLN and that of the integrin αEβ7+ cells in the IEL, suggesting an enhancement of the homing process of naïve T lymphocytes to the MLN, and the retention of activated lymphocytes in the intraepithelial compartment. Interestingly, B. breve M-16V enhanced the intestinal IgA synthesis. In conclusion, supplementation with the probiotic strain B. breve M-16V during suckling improves the development of mucosal immunity in early life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.