ArticleNature chemical biology2017
Dereplication of peptidic natural products through database search of mass spectra.
Article in Nature chemical biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers.
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Who cites it
121 citing papers in PubMed.
- Annotation and Dereplication of Peptidic Natural Products (PNPs).Methods in molecular biology (Clifton, N.J.) · 2027Article
- MetaboAnnotate: An AI-powered Multiagent Framework for Integrating Annotation Tools for Untargeted Metabolomics.Analytical chemistry · 2026Article
- Paenitracins, a novel family of bacitracin-type nonribosomal peptide antibiotics produced by plant-associatedmSystems · 2026Article
- The undiscovered natural product potential of Actinomycetes.The Journal of antibiotics · 2026Article
- Experimental and computational approaches for deep metabolome annotation with application to the ecotoxicological model organism Daphnia magna.GigaScience · 2026Article
- Discovery, biosynthesis, and bioactivities of peptidic natural products from marine sponges and sponge-associated bacteria.Natural product reports · 2025Review
- Hidden gems of Benin: Unravelling the diversity ofPersoonia · 2025Article
- Chemodiversity of Cyanobacteria from Brazil Investigated by Metabolomics and Bioassays.ACS omega · 2025Article
- Genomic and Metabolomic Insights into Metabolites of aMarine drugs · 2025Article
- Seq2Saccharide: Discovering Oligosaccharides and Aminoglycosides Natural Products by Integrating Computational Mass Spectrometry and Genome Mining.Journal of the American Chemical Society · 2025Article
- An integrated multi-omic approach for discovery and dereplication of bioactive microbial natural products.Microbial genomics · 2025Article
- Contact- and Water-Mediated Interactions With an Allelopathic Macroalga Drive Distinct Coral Microbiome and Metabolome.Environmental microbiology · 2025Article
- Efficient mining of natural products from Mangrove streptomyces using NP-PRESS.Archives of microbiology · 2025Article
- Menominin A and B: Cytotoxic Cyclodepsipeptides from the Freshwater Sponge-Associated CyanobacteriumJournal of natural products · 2025Article
- Discovering organic reactions with a machine-learning-powered deciphering of tera-scale mass spectrometry data.Nature communications · 2025Article
- Complete Genome Sequence, Biological Activities, and Metabolomic Profiles of Mangrove-Derived Streptomyces sp. SM1P.Current microbiology · 2025Article
- Integrative metabolo-genomics suggests a biosynthetic pathway for tetrangulol in Streptomyces sp. KL110A.World journal of microbiology & biotechnology · 2025Article
- Presence of polyketide synthases and nonribosomal peptide synthetase in culturable bacteria associated with Aplysina fulva and Aplysina caissara (Porifera).Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Discovery of Peptidic Siderophore Degradation by Screening Natural Product Profiles in Marine-Derived Bacterial Mono- and Cocultures.Biochemistry · 2025Article
- Invasive macroalgae shape chemical and microbial waterscapes on coral reefs.Communications biology · 2025Article
61 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors.
Funding
Abstract
Peptidic natural products (PNPs) are widely used compounds that include many antibiotics and a variety of other bioactive peptides. Although recent breakthroughs in PNP discovery raised the challenge of developing new algorithms for their analysis, identification of PNPs via database search of tandem mass spectra remains an open problem. To address this problem, natural product researchers use dereplication strategies that identify known PNPs and lead to the discovery of new ones, even in cases when the reference spectra are not present in existing spectral libraries. DEREPLICATOR is a new dereplication algorithm that enables high-throughput PNP identification and that is compatible with large-scale mass-spectrometry-based screening platforms for natural product discovery. After searching nearly one hundred million tandem mass spectra in the Global Natural Products Social (GNPS) molecular networking infrastructure, DEREPLICATOR identified an order of magnitude more PNPs (and their new variants) than any previous dereplication efforts.
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