Evidence map›Paper›PMID 27820800›Full record

ArticleNature chemical biology2017

Identification of G-quadruplexes in long functional RNAs using 7-deazaguanine RNA.

Carika Weldon, Isabelle Behm-Ansmant, Laurence H Hurley, Glenn A Burley, Christiane Branlant, Ian C Eperon, Cyril Dominguez

Open access · bronzeAbstract read
In one paragraph

Article in Nature chemical biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 73 citations in OpenAlex.

  1. Article
  2. Article
  3. RNA tertiary structure and conformational dynamics revealed by BASH MaP.bioRxiv : the preprint server for biology · 2024
    Article
  4. Article
  5. Article
  6. Review
  7. G-Quadruplexes Regulate miRNA Biogenesis in Live Zebrafish Embryos.International journal of molecular sciences · 2023
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. STRs: Ancient Architectures of the Genome beyond the Sequence.Journal of molecular neuroscience : MN · 2021
    Review
  13. Article
  14. Aberrant Bcl-x splicing in cancer: from molecular mechanism to therapeutic modulation.Journal of experimental & clinical cancer research : CR · 2021
    Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Carika WeldonLeicester Institute of Structural and Chemical Biology and Department of Molecular and Cell Biology, University of Leicester, Leicester, UK.
Isabelle Behm-AnsmantIMoPA (Ingénierie Moléculaire et Physiopathologie Articulaire), UMR 7365 Centre National de la Recherche Scientifique (CNRS)-UL, Biopôle de l'Université de Lorraine, Vandoeuvre-lès-Nancy, France.
Laurence H HurleyCollege of Pharmacy and BIO5 Institute, University of Arizona, Tucson, Arizona, USA.
Glenn A BurleyDepartment of Pure and Applied Chemistry, University of Strathclyde, Glasgow, UK.
Christiane BranlantIMoPA (Ingénierie Moléculaire et Physiopathologie Articulaire), UMR 7365 Centre National de la Recherche Scientifique (CNRS)-UL, Biopôle de l'Université de Lorraine, Vandoeuvre-lès-Nancy, France.
Ian C EperonLeicester Institute of Structural and Chemical Biology and Department of Molecular and Cell Biology, University of Leicester, Leicester, UK.
Cyril DominguezLeicester Institute of Structural and Chemical Biology and Department of Molecular and Cell Biology, University of Leicester, Leicester, UK.ORCID http://orcid.org/0000-0003-3575-8922
University of Leicester · GBCentre National de la Recherche Scientifique · FRUniversity of Arizona · USUniversity of Strathclyde · GB

Funding

Medical Research Council G1000526
6 · The paper itself

Abstract

RNA G-quadruplex (G4) structures are thought to affect biological processes, including translation and pre-mRNA splicing, but it is not possible at present to demonstrate that they form naturally at specific sequences in long functional RNA molecules. We developed a new strategy, footprinting of long 7-deazaguanine-substituted RNAs (FOLDeR), that allows the formation of G4s to be confirmed in long RNAs and under functional conditions.

Indexed as

G-QuadruplexesGuanineHumansRNA7-deazaguanineGuanineRNA

Identifiers

PMID27820800
PMCPMC5164935
OpenAlexW2547929719

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.