Evidence map›Paper›PMID 27820670›Full record

Trial reportOphthalmic epidemiology2016

Surveillance and Azithromycin Treatment for Newcomers and Travelers Evaluation (ASANTE) Trial: Design and Baseline Characteristics.

Ann-Margret Ervin, Harran Mkocha, Beatriz Munoz, Kurt Dreger, Laura Dize, Charlotte Gaydos, Thomas C Quinn, Sheila K West

Open access · greenAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Ophthalmic epidemiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Ann-Margret Ervina Dana Center for Preventive Ophthalmology, Wilmer Eye Institute , Johns Hopkins University , Baltimore , MD , USA.
Harran Mkochac Kongwa Trachoma Project , Kongwa , Tanzania.
Beatriz Munoza Dana Center for Preventive Ophthalmology, Wilmer Eye Institute , Johns Hopkins University , Baltimore , MD , USA.
Kurt Dregera Dana Center for Preventive Ophthalmology, Wilmer Eye Institute , Johns Hopkins University , Baltimore , MD , USA.
Laura Dized International Chlamydia Laboratory, Department of Medicine , Johns Hopkins University , Baltimore , MD , USA.
Charlotte Gaydosd International Chlamydia Laboratory, Department of Medicine , Johns Hopkins University , Baltimore , MD , USA.
Thomas C Quinnd International Chlamydia Laboratory, Department of Medicine , Johns Hopkins University , Baltimore , MD , USA.
Sheila K Westa Dana Center for Preventive Ophthalmology, Wilmer Eye Institute , Johns Hopkins University , Baltimore , MD , USA.
Johns Hopkins University · USJohns Hopkins Medicine · US

Funding

Immunopathogenesis Of Chlamydia trachomatis InfectionZIAAI000358 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI QUINN, THOMAS · 2009 to 2022
$7.0M
Surveillance & Treatment of Community Newcomers & Travelers for Trachoma ControlU10EY022584 · NEI · JOHNS HOPKINS UNIVERSITY · PI WEST, SHEILA K · 2012 to 2015
$4.5M
NEI NIH HHS U10 EY022584
6 · The paper itself

Abstract

purposeImmigrants and travelers may be sources of re-emergent infection in trachoma-endemic communities close to trachoma elimination. The primary objective of the A Surveillance and Azithromycin Treatment for Newcomers and Travelers Evaluation (ASANTE) trial was to determine whether a newcomer and traveler surveillance and treatment program in addition to annual mass drug administration (MDA) would reduce Chlamydia trachomatis infection when compared to MDA alone.

methodsASANTE was a randomized controlled trial in 52 communities in Kongwa, Tanzania. In 26 intervention communities, monitors treated everyone in new households, in-coming children and guardians in existing households, and all persons in households who had traveled between annual MDA events. A total of 26 usual practice communities received MDA only. Surveys of 100 1-9-year-olds from each community were conducted at baseline and every 6 months up to 2 years to assess clinical trachoma and C. trachomatis infection. Data on demographics and environmental factors were also collected.

resultsMean prevalences of trachomatous inflammation - follicular (TF) and C. trachomatis were equivalent between the two arms (5.2% and 3.7% in intervention, and 4.9% and 3.6% in usual practice communities, respectively). Of 318 children with TF, 36.5% tested positive for C. trachomatis. TF prevalence was higher among households without a bicycle (p = 0.03) and lower with increasing child's age (p < 0.001). Infection prevalence was higher among households >30 minutes from water (p = 0.015). TF and infection prevalence decreased with increasing years of education (p = 0.004 and p = 0.002, respectively).

conclusionThe ASANTE trial will inform guidance on the surveillance and treatment of persons traveling or newly arriving to communities hypo-endemic for trachoma.

Indexed as

Anti-Bacterial AgentsAzithromycinChildChild, PreschoolEmigrants and ImmigrantsFemaleHumansInfantMaleNeglected DiseasesPopulation SurveillancePrevalenceRisk FactorsTanzaniaTrachomaAnti-Bacterial AgentsAzithromycinChlamydia trachomatiscommunity-basedrandomized controlled trialsurveillanceTanzaniatrachoma

Identifiers

PMID27820670
PMCPMC5279916
OpenAlexW2552455816

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.