ArticleNature genetics2016
A cis cold memory element and a trans epigenome reader mediate Polycomb silencing of FLC by vernalization in Arabidopsis.
Article in Nature genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers.
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91 citing papers in PubMed, 195 citations in OpenAlex.
- Physiology and Genetics of Continuous Flowering in Plants.Plant, cell & environment · 2026Review
- Molecular integration of seasonal temperature signals in flowering time control.Nature reviews. Genetics · 2026Review
- Epigenetic Control of Cold Stress Tolerance in Plants: Emerging Mechanisms and Applications for Crop Improvement.International journal of molecular sciences · 2026Review
- The environmentally responsive plant epigenome: insights from jasmonate signaling.The New phytologist · 2026Review
- ZINC FINGER PROTEIN 1 and 8 interact with polycomb repressive complex 2 to repress class B and C floral organ identity genes.Nucleic acids research · 2026Article
- A histone deacetylase complex regulates anthocyanin biosynthesis during normal plant growth and development and in response to jasmonate.Plant communications · 2026Article
- cis- and trans-elements for the transcriptional regulation of sugar responsive genes: from current knowledge to future applications.Plant molecular biology · 2025Review
- Cis- and trans-action of the cold-induced lncRNAs, SVALKA and SVALNA, regulate CBF1 and CBF3 in Arabidopsis.EMBO reports · 2025Article
- CK2 kinase-PRC2 signalling regulates genome-wide H3K27 trimethylation and transduces prolonged cold exposure into epigenetic cold memory in plants.Nature plants · 2025Article
- Epigenetics in the modern era of crop improvements.Science China. Life sciences · 2025Review
- The transcriptional regulator VAL1 promotes Arabidopsis flowering by repressing the organ boundary genes BOP1 and BOP2.Plant physiology · 2025Article
- Alternative silencing states of transposable elements in Arabidopsis associated with H3K27me3.Genome biology · 2025Article
- PtABI3 represses the age biomarker geneForestry research · 2025Article
- EMBRYONIC FLOWER 1 regulates male reproduction by repressing the jasmonate pathway downstream transcription factor MYB26.The Plant cell · 2024Article
- Co-repressors AtSDR4L and DIG1 interact with transcription factor VAL2 and promote Arabidopsis seed-to-seedling transition.Plant physiology · 2024Article
- Exogenous abscisic acid represses rice flowering via SAPK8-ABF1-Ehd1/Ehd2 pathway.Journal of advanced research · 2024Article
- Epigenetic variation in early and late flowering plants of the rubber-producing Russian dandelion Taraxacum koksaghyz provides insights into the regulation of flowering time.Scientific reports · 2024Article
- Application of genome editing techniques to regulate gene expression in crops.BMC plant biology · 2024Review
- Identification of vernalization-related genes and cold memory element (CME) required for vernalization response in radish (Raphanus sativus L.).Plant molecular biology · 2024Article
- LHP1-mediated epigenetic buffering of subgenome diversity and defense responses confers genome plasticity and adaptability in allopolyploid wheat.Nature communications · 2023Article
31 more citing papers are in PubMed but not listed here.
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8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Some plants acquire competence to flower in spring after experiencing a seasonal temperature drop-winter cold, in a process termed vernalization. In Arabidopsis thaliana, prolonged exposure to cold induces epigenetic silencing of the potent floral repressor locus FLOWERING LOCUS C (FLC) by Polycomb group (PcG) proteins, and this silencing is stably maintained in subsequent growth and development upon return to warm temperatures. Here we show that a cis-regulatory DNA element in the nucleation region for PcG silencing at FLC and two homologous trans-acting epigenome readers, VAL1 and VAL2, control vernalization-mediated FLC silencing. The sequence-specific readers recognize both the cis element (termed the cold memory element) and a repressive mark, trimethylation of histone H3 at lysine 27 (H3K27me3), and directly associate with LIKE HETEROCHROMATIN PROTEIN 1 (LHP1), leading to establishment of the H3K27me3 peak in the nucleation region at FLC during vernalization. Thus, our work describes a mechanism for PcG-mediated silencing by a DNA sequence-specific epigenome reader.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.