Evidence map›Paper›PMID 27819528›Full record

ArticleImmunological investigations2017

Interferon-gamma (IFN-γ) is Elevated in Wound Exudate from Hidradenitis Suppurativa.

Anirban Banerjee, Sean McNish, Victoria K Shanmugam

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunological investigations, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 4 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 4 syntheses or guidelines pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Pooled it
  5. Trial
  6. Article
  7. Review
  8. Article
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  10. Article
  11. Wound fluid sampling methods for proteomic studies: A scoping review.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2022
    Article
  12. New and Emerging Targeted Therapies for Hidradenitis Suppurativa.International journal of molecular sciences · 2022
    Review
  13. Article
  14. Review
  15. Review
  16. Hidradenitis Suppurativa: Host-Microbe and Immune Pathogenesis Underlie Important Future Directions.JID innovations : skin science from molecules to population health · 2021
    Review
  17. Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Anirban Banerjeea Division of Rheumatology , The George Washington University, School of Medicine and Health Sciences , Washington , DC , USA.
Sean McNisha Division of Rheumatology , The George Washington University, School of Medicine and Health Sciences , Washington , DC , USA.
Victoria K Shanmugama Division of Rheumatology , The George Washington University, School of Medicine and Health Sciences , Washington , DC , USA.
George Washington University · US

Funding

Clinical and Translational Science Institute at Children's NationalUL1TR000075 · NCATS · CHILDREN'S RESEARCH INSTITUTE · PI GUAY-WOODFORD, LISA MARIE · 2012 to 2015
$13.7M
Genomics, Biomarkers and Mechanisms of Healing in Chronic WoundsR01NR013888 · NINR · GEORGE WASHINGTON UNIVERSITY · PI SHANMUGAM, VICTORIA KATE · 2012 to 2016
$1.9M
NCATS NIH HHS UL1 TR000075NINR NIH HHS R01 NR013888
6 · The paper itself

Abstract

Hidradenitis suppurativa (HS) is a chronic recurrent inflammatory disease of apocrine glands which affects 1-4% of young adults. The purpose of this study was to investigate inflammatory cytokines in effluent from HS lesions and to identify potential local drivers of inflammation in HS. Wound fluid specimens from HS patients (n = 8) and age-matched chronic wound patients (n = 8) were selected for analysis. The hidradenitis suppurativa score (HSS) was used to determine the extent of HS activity. Cytokine analysis was conducted using Meso Scale Discovery cytokine and proinflammatory panels. Interferon-gamma (IFN-γ) was significantly elevated in the HS effluent compared to chronic wounds (1418 ± 1501 pg/ml compared to 102.5 ± 138 pg/ml, p = 0.027). HS effluent also had significantly higher levels of tumor necrosis factor-β (TNF-β) (9.24 ± 7.22 pg/ml compared to 1.65 ± 2.14 pg/ml, p = 0.03). There was no significant difference in any other cytokines. There was no significant difference in demographics in the HS compared to chronic wound cohorts. Mean HSS in the HS cohort was 68.88 (SD ± 41.45). In this proof-of-concept pilot study, IFN-γ was significantly elevated in HS effluent. TNF-β/LT-α levels were also elevated in HS, although the levels were more modest. Further studies should focus on molecular drivers of tissue injury in HS and the relationship between HS effluent cytokine profile and disease activity.

Indexed as

AdultApocrine GlandsCohort StudiesDisease ProgressionExudates and TransudatesFemaleHidradenitis SuppurativaHumansInterferon-gammaLymphotoxin-alphaMaleMiddle AgedPilot ProjectsUp-RegulationWounds and InjuriesInterferon-gammaLymphotoxin-alphaCytokinehidradenitis suppurativaIFN-γulcerwoundwound effluentwound fluid

Identifiers

PMID27819528
PMCPMC5767159
OpenAlexW2556792921

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.