ArticleScientific reports2016
A new method for measuring lung deposition efficiency of airborne nanoparticles in a single breath.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Aerosol deposition in the lung as a biomarker in asthma and chronic obstruction.Respiratory research · 2026Article
- Activation of regenerative pathways by exercise intervention in subjects with chronic obstructive pulmonary disease - a study protocol.Respiratory research · 2025Article
- Patient-specific estimation of distal lung morphometry using aerosol deposition data.Frontiers in physiology · 2025Article
- Enlarged airspaces in the distal lung in adolescents born very preterm as measured by aerosol.BMJ open respiratory research · 2024Article
- An experimental study on lung deposition of inhaled 2 μm particles in relation to lung characteristics and deposition models.Particle and fibre toxicology · 2023Article
- Smart Radiotherapy Biomaterials for Image-Guided In Situ Cancer Vaccination.Nanomaterials (Basel, Switzerland) · 2023Review
- Airspace Dimension Assessment for early detection of lung function impairment in the peripheral airways of firefighters.ERJ open research · 2023Article
- Aerosolised micro and nanoparticle: formulation and delivery method for lung imaging.Clinical and translational imaging · 2023Review
- A novel in-situ method to determine the respiratory tract deposition of carbonaceous particles reveals dangers of public commuting in highly polluted megacity.Particle and fibre toxicology · 2022Article
- Airspace Dimension Assessment with Nanoparticles (AiDA) in Comparison to Established Pulmonary Function Tests.International journal of nanomedicine · 2022Article
- Airspace dimension assessment with nanoparticles as a proposed biomarker for emphysema.Thorax · 2021Article
- Airspace Dimension Assessment (AiDA) by inhaled nanoparticles: benchmarking with hyperpolarisedScientific reports · 2021Article
- Altered deposition of inhaled nanoparticles in subjects with chronic obstructive pulmonary disease.BMC pulmonary medicine · 2018Article
- Airspace Dimension Assessment with nanoparticles reflects lung density as quantified by MRI.International journal of nanomedicine · 2018Article
- A Miniature Aerosol Sensor for Detecting Polydisperse Airborne Ultrafine Particles.Sensors (Basel, Switzerland) · 2017Article
- Do nanoparticles provide a new opportunity for diagnosis of distal airspace disease?International journal of nanomedicineArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Assessment of respiratory tract deposition of nanoparticles is a key link to understanding their health impacts. An instrument was developed to measure respiratory tract deposition of nanoparticles in a single breath. Monodisperse nanoparticles are generated, inhaled and sampled from a determined volumetric lung depth after a controlled residence time in the lung. The instrument was characterized for sensitivity to inter-subject variability, particle size (22, 50, 75 and 100 nm) and breath-holding time (3-20 s) in a group of seven healthy subjects. The measured particle recovery had an inter-subject variability 26-50 times larger than the measurement uncertainty and the results for various particle sizes and breath-holding times were in accordance with the theory for Brownian diffusion and values calculated from the Multiple-Path Particle Dosimetry model. The recovery was found to be determined by residence time and particle size, while respiratory flow-rate had minor importance in the studied range 1-10 L/s. The instrument will be used to investigate deposition of nanoparticles in patients with respiratory disease. The fast and precise measurement allows for both diagnostic applications, where the disease may be identified based on particle recovery, and for studies with controlled delivery of aerosol-based nanomedicine to specific regions of the lungs.
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