ArticleScientific reports2016
IL-21 signaling is essential for optimal host resistance against Mycobacterium tuberculosis infection.
Open access · goldAbstract read
In one paragraph
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 43 citations in OpenAlex.
- The study of immunological markers in tuberculosis across animal models and its translation to human research.Lab animal · 2026Review
- Modulation of pulmonary IL-21 expression during latent TB and M. tuberculosis/SIV coinfection.JCI insight · 2026Article
- IFNγ blockade in Mycobacterium tuberculosis infected macaques alters the granuloma environment but not bacterial control.Nature communications · 2026Article
- CD226 identifies effector CD8Cell reports · 2025Article
- Advances in host-directed therapy for tuberculosis and HIV coinfection: enhancing immune responses.Trends in microbiology · 2025Review
- Acute Exposure to Aerosolized Nanoplastics Modulates Redox-Linked Immune Responses in Human Airway Epithelium.Antioxidants (Basel, Switzerland) · 2025Article
- CD4 T cell dysfunction is associated with bacterial recrudescence during chronic tuberculosis.Nature communications · 2025Article
- CD4 T cell dysfunction is associated with bacterial recrudescence during chronic tuberculosis.bioRxiv : the preprint server for biology · 2025Article
- Recently activated CD4 T cells in tuberculosis express OX40 as a target for host-directed immunotherapy.Nature communications · 2023Article
- IL-21/IL-21R Promotes the Pro-Inflammatory Effects of Macrophages duringInternational journal of molecular sciences · 2023Article
- CTLs: Killers of intracellular bacteria.Frontiers in cellular and infection microbiology · 2022Review
- Exploring the association between Th17 pathway gene polymorphisms and pulmonary tuberculosis.Frontiers in immunology · 2022Article
- MicroRNA-30b Is Both Necessary and Sufficient for Interleukin-21 Receptor-Mediated Angiogenesis in Experimental Peripheral Arterial Disease.International journal of molecular sciences · 2021Article
- CD4 T cell help prevents CD8 T cell exhaustion and promotes control of Mycobacterium tuberculosis infection.Cell reports · 2021Article
- Coreceptor therapy has distinct short- and long-term tolerogenic effects intrinsic to autoreactive effector T cells.JCI insight · 2021Article
- Mycobacterium tuberculosis-specific CD4 T cells expressing CD153 inversely associate with bacterial load and disease severity in human tuberculosis.Mucosal immunology · 2021Article
- MR1-Restricted MAIT Cells From The Human Lung Mucosal Surface Have Distinct Phenotypic, Functional, and Transcriptomic Features That Are Preserved in HIV Infection.Frontiers in immunology · 2021Article
- Article
- RNA Sensing ofVaccines · 2020Review
- A Bovine EntericFrontiers in immunology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Matthew G BootyDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts 01655, US.
Palmira Barreira-SilvaDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts 01655, US.
Stephen M CarpenterDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts 01655, US.
Cláudio Nunes-AlvesDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts 01655, US.
Miye K JacquesDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts 01655, US.
Britni L StowellDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts 01655, US.
Pushpa JayaramanDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts 01655, US.
Gillian BeamerDepartment of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, Grafton, MA 01536, US.
Samuel M BeharDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts 01655, US.
University of Massachusetts Chan Medical School · USTufts University · US
Funding
Transgenic / Knock-out mouse coreP01AI073748 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI BEHAR, SAMUEL M · 2008 to 2019
$17.1MRegulation of CD8+ T cell immunity to tuberculosis (pending title)R01AI106725 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BEHAR, SAMUEL M · 2013 to 2022
$6.1MTRAINING IN IMMUNOLOGY (COMPETITIVE RENEWAL OF AI07439)T32AI007349 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI STERN, LAWRENCE J. · 1989 to 2024
$4.5MThe effect of type I IFN and IL-12 signaling on T cell immunity to tuberculosisR21AI100766 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BEHAR, SAMUEL M · 2012 to 2013
$438kNIAID NIH HHS P01 AI073748NIAID NIH HHS R01 AI106725NIAID NIH HHS R21 AI100766NIAID NIH HHS T32 AI007349
Abstract
IL-21 is produced predominantly by activated CD4
Indexed as
AnimalsBiomarkersBone Marrow CellsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCytokinesDisease ResistanceFemaleHepatitis A Virus Cellular Receptor 2Interferon-gammaInterleukin-21InterleukinsLungMiceMice, Inbred C57BLMice, KnockoutBiomarkersCytokinesHavcr2 protein, mouseHepatitis A Virus Cellular Receptor 2Interferon-gammaInterleukin-21InterleukinsPdcd1 protein, mouseProgrammed Cell Death 1 Receptor
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.