ArticleScientific reports2016
SIRT1 deacetylates the cardiac transcription factor Nkx2.5 and inhibits its transcriptional activity.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Article
- Tmem88 confines ectodermal Wnt2bb signaling in pharyngeal arch artery progenitors for balancing cell cycle progression and cell fate decision.Nature cardiovascular research · 2023Article
- SIRT6 in Vascular Diseases, from Bench to Bedside.Aging and disease · 2022Article
- miR-146a impedes the anti-aging effect of AMPK via NAMPT suppression and NADSignal transduction and targeted therapy · 2022Article
- Sirtuin Family and Diabetic Kidney Disease.Frontiers in endocrinology · 2022Review
- DNAJC12 promotes lung cancer growth by regulating the activation of β‑catenin.International journal of molecular medicine · 2021Article
- PHD Finger Protein 19 Promotes Cardiac Hypertrophy via Epigenetically Regulating SIRT2.Cardiovascular toxicology · 2021Article
- KLK11 promotes the activation of mTOR and protein synthesis to facilitate cardiac hypertrophy.BMC cardiovascular disorders · 2021Article
- SIRT1 Inhibits High Shear Stress-Induced Apoptosis in Rat Cortical Neurons.Cellular and molecular bioengineering · 2020Article
- HTR2A promotes the development of cardiac hypertrophy by activating PI3K-PDK1-AKT-mTOR signaling.Cell stress & chaperones · 2020Article
- Divergent Transcription of theiScience · 2020Article
- Carboxypeptidase A4 promotes cardiomyocyte hypertrophy through activating PI3K-AKT-mTOR signaling.Bioscience reports · 2020Article
- Alterations of Transcription of Genes Coding Anti-oxidative and Mitochondria-Related Proteins in Amyloid β Toxicity: Relevance to Alzheimer's Disease.Molecular neurobiology · 2020Article
- The Histone Demethylase JMJD1C Regulates CAMKK2-AMPK Signaling to Participate in Cardiac Hypertrophy.Frontiers in physiology · 2020Article
- Usefulness of resveratrol supplementation in decreasing cardiometabolic risk factors comparing subjects with metabolic syndrome and healthy subjects with or without obesity: meta-analysis using multinational, randomised, controlled trials.Archives of medical sciences. Atherosclerotic diseases · 2020Article
- Cardiomyocyte Senescence and Cellular Communications Within Myocardial Microenvironments.Frontiers in endocrinology · 2020Review
- JMJD1A Represses the Development of Cardiomyocyte Hypertrophy by Regulating the Expression ofBioMed research international · 2020Article
- Sirt2 epigenetically down-regulates PDGFRα expression and promotes CG4 cell differentiation.Cell cycle (Georgetown, Tex.) · 2019Article
- Epigenetic and non-epigenetic mode of SIRT1 action during oocyte meiosis progression.Journal of animal science and biotechnology · 2019Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The homeodomain transcription factor Nkx2.5/Csx is critically essential for heart specification, morphogenesis, and homeostasis. Acetylation/deacetylation is important for the localization, stability and activation of transcription factors. It remains unknown how Nkx2.5 is deacetylated and how Nkx2.5 acetylation determines its activity. In this study, we provide evidence that the NAD
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.