Evidence map›Paper›PMID 27819215›Full record

Trial reportPublic health nutrition2017

Dietary iron and calcium intakes during pregnancy are associated with lower risk of prematurity, stillbirth and neonatal mortality among women in Tanzania.

Dominic Mosha, Enju Liu, Ellen Hertzmark, Grace Chan, Christopher Sudfeld, Honorati Masanja, Wafaie Fawzi

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Public health nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  13. Review
  14. Adequacy of Nutrients Intake among Jordanian Pregnant Women in Comparison to Dietary Reference Intakes.International journal of environmental research and public health · 2019
    Article
  15. Article
  16. Article
  17. Assessment of dietary intake and mineral status in pregnant women.Archives of gynecology and obstetrics · 2018
    Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dominic Mosha1Rufiji Health and Demographic Surveillance System,Ifakara Health Institute,Rufiji,PO Box 78373,Dar es Salaam,Tanzania.
Enju Liu2Department of Global Health and Population,Harvard T.H. Chan School of Public Health,Boston,MA,USA.
Ellen Hertzmark2Department of Global Health and Population,Harvard T.H. Chan School of Public Health,Boston,MA,USA.
Grace Chan2Department of Global Health and Population,Harvard T.H. Chan School of Public Health,Boston,MA,USA.
Christopher Sudfeld2Department of Global Health and Population,Harvard T.H. Chan School of Public Health,Boston,MA,USA.
Honorati Masanja1Rufiji Health and Demographic Surveillance System,Ifakara Health Institute,Rufiji,PO Box 78373,Dar es Salaam,Tanzania.
Wafaie Fawzi2Department of Global Health and Population,Harvard T.H. Chan School of Public Health,Boston,MA,USA.

Funding

Tanzania Infectious Disease Research Training ProgramD43TW007886 · FIC · HARVARD SCHOOL OF PUBLIC HEALTH · PI FAWZI, WAFAIE W · 2007 to 2018
$1.9M
FIC NIH HHS D43 TW007886
6 · The paper itself

Abstract

objectivePrematurity, stillbirth and other adverse birth outcomes remain major concerns in resource-limited settings. Poor dietary intake of micronutrients during pregnancy has been associated with increased risk of adverse outcomes. We determined the relationships between dietary Fe and Ca intakes during pregnancy and risks of adverse birth outcomes among HIV-negative women.

designWomen's diet was assessed through repeated 24 h diet recalls in pregnancy. Mean intakes of total Fe, Fe from animal sources and Ca during pregnancy were examined in relation to adverse birth outcomes and neonatal mortality. Women were prescribed daily Fe supplements as per standard perinatal care.

settingDar es Salaam, Tanzania. SUBJECTS: A cohort of 7634 pregnant women.

resultsMedian (interquartile range) daily dietary intake of total Fe, animal Fe and Ca was 11·9 (9·3-14·7), 0·5 (0-1·1) and 383·9 (187·4-741·2) mg, respectively. Total Fe intake was significantly associated with reduced risk of stillbirth (trend over quartiles, P=0·010). Animal Fe intake was significantly associated with reduced risk of preterm birth and extreme preterm birth. Animal Fe intake was inversely related to neonatal mortality risk; compared with women in the lowest intake quartile, those in the top quartile were 0·51 times as likely to have neonatal death (95 % CI 0·33, 0·77). Higher Ca intake was associated with reduced risk of preterm birth (relative risk; 95 % CI: 0·76; 0·65, 0·88) and extreme preterm birth (0·63; 0·47, 0·86). Women in the highest Ca intake quartile had reduced risk of neonatal mortality (0·59; 0·37, 0·92).

conclusionsDaily dietary Fe and Ca intakes among pregnant women are very low. Improvement of women's diet quality during gestation is likely to improve the risks of adverse birth outcomes.

Indexed as

Infant MortalityAdultCalcium, DietaryCohort StudiesDietDiet RecordsFemaleHumansInfantIron, DietaryPregnancyPremature BirthProspective StudiesRiskStillbirthTanzaniaCalcium, DietaryIron, DietaryCalciumDietIronNeonatal mortalityPregnancyPrematurityStillbirth

Identifiers

PMID27819215
PMCPMC5387760

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.