ArticleJournal of neurology & neuromedicine2016
Primary age-related tauopathy and the amyloid cascade hypothesis: the exception that proves the rule?
Article in Journal of neurology & neuromedicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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Who cites it
41 citing papers in PubMed.
- Primary age-related tauopathy.Acta neuropathologica · 2025Review
- Alzheimer mimicry: LATE and PART.Journal of neural transmission (Vienna, Austria : 1996) · 2025Review
- Cognitive decline in community-dwelling older persons with primary age-related tauopathy: role of anatomical location of tangles and other co-existing brain pathologies.Acta neuropathologica · 2025Article
- Amyloid-β oligomers increase the binding and internalization of tau oligomers in human synapses.Acta neuropathologica · 2024Article
- Disentangling and quantifying the relative cognitive impact of concurrent mixed neurodegenerative pathologies.Acta neuropathologica · 2024Article
- Spatial proteomics of hippocampal subfield-specific pathology in Alzheimer's disease and primary age-related tauopathy.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Pathological Markers of Alzheimer's Disease and Related Dementia in the Rhesus Macaque Amygdala.Journal of Alzheimer's disease reports · 2024Article
- A data-driven study of Alzheimer's disease related amyloid and tau pathology progression.Brain : a journal of neurology · 2023Observational
- Prognostic value of imaging-based ATN profiles in a memory clinic cohort.European journal of nuclear medicine and molecular imaging · 2023Article
- The relationship between hippocampal amyloid beta burden and spatial distribution of neurofibrillary degeneration.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Chronic traumatic encephalopathy (CTE): criteria for neuropathological diagnosis and relationship to repetitive head impacts.Acta neuropathologica · 2023Review
- Tau; One Protein, So Many Diseases.Biology · 2023Review
- Cognitive resistance to and resilience against multiple comorbid neurodegenerative pathologies and the impact of APOE status.Journal of neuropathology and experimental neurology · 2023Article
- Cognitive and Neuropsychological Profiles in Alzheimer's Disease and Primary Age-Related Tauopathy and the Influence of Comorbid Neuropathologies.Journal of Alzheimer's disease : JAD · 2023Article
- Divergent magnetic resonance imaging atrophy patterns in Alzheimer's disease and primary age-related tauopathy.Neurobiology of aging · 2022Article
- Abnormal tau in amyloid PET negative individuals.Neurobiology of aging · 2022Article
- Decreased Global EEG Synchronization in Amyloid Positive Mild Cognitive Impairment and Alzheimer's Disease Patients-Relationship toBrain sciences · 2021Article
- Article
- Predictors of cognitive impairment in primary age-related tauopathy: an autopsy study.Acta neuropathologica communications · 2021Article
- Asymmetry of Hippocampal Tau Pathology in Primary Age-Related Tauopathy and Alzheimer Disease.Journal of neuropathology and experimental neurology · 2021Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Extensive data supports the amyloid cascade hypothesis, which states that Alzheimer's disease (AD) stems from neurotoxic forms of the amyloid-beta (Aβ) peptide. But the poor correlation between Aβ plaques and neurodegeneration/cognitive impairment, the spaciotemporal disparity between Aβ and tau pathology, and the disappointing results following several large clinical trials using Aβ-targeting agents are inconsistent with this explanation. The most perplexing inconsistency is the existence of AD-type dementia patients that develop abundant neurofibrillary tangles that are indistinguishable from those in early to moderate-stage AD in the absence of compelling evidence of amyloid toxicity. This neuropathological phenotype, which is distinct from other diseases with tangles, represents a conceptual disconnect, because it does not fall within any previously established category of tauopathy and ostensibly invalidates the amyloid cascade hypothesis. Instead, recent efforts have led to consensus criteria for a new alternative diagnostic category, which presupposes that these tangle-only dementia patients represent extreme examples of a distinct primary age-related tauopathy (PART) that is universally observed, albeit to varying degrees, in the aging brain. The cause of PART is unknown, but sufficient evidence exists to hypothesize that it stems from an Aβ-independent mechanism, such as mechanical injury. Should the PART hypothesis withstand further experimental testing, it would represent a shift in the way a subset of subjects with AD neuropathological change are classified and has the potential to focus and reaffirm the amyloid cascade hypothesis.
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Registered trials
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