ArticleMolecular metabolism2016
Modulation of ambient temperature promotes inflammation and initiates atherosclerosis in wild type C57BL/6 mice.
Article in Molecular metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
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Who cites it
53 citing papers in PubMed, 81 citations in OpenAlex.
- Western diet-induced MASH in PWK/PhJ mice identifies disruptions in amino acid and sphingolipid metabolism contributing to cardiac dysfunction.Nature communications · 2026Article
- Ambient temperature regulates CD4iScience · 2026Article
- PNPLA3-I148M reduces hepatic triacylglycerol secretion and mitigates diet induced left ventricular diastolic dysfunction.Scientific reports · 2026Article
- The effects of housing temperature on mouse physiology and implications for disease modeling.Lab animal · 2026Review
- Thermoneutral housing worsens MASLD and reveals defective brown adipose tissue response to β3-adrenergic stimulation.iScience · 2025Article
- Housing matters: Experimental variables shaping metabolism in obese mice.Molecular metabolism · 2025Article
- Animal Models of Exercise and Cardiometabolic Disease.Circulation research · 2025Review
- The evolution of steatosis and fibrosis in mice on a MASH-inducing diet and the effects of housing temperature.American journal of physiology. Endocrinology and metabolism · 2025Article
- Article
- Housing mice near vs. below thermoneutrality affects drug-induced weight loss but does not improve prediction of efficacy in humans.Cell reports · 2024Article
- Exploring the effect of a sweltering environment on the risk of death from cardiovascular diseases.Frontiers in neurology · 2024Article
- Impact of housing temperature on adipose tissue HDAC9 expression and adipogenic differentiation in high fat-fed mice.Obesity (Silver Spring, Md.) · 2024Article
- Obesity amplifies influenza virus-driven disease severity in male and female mice.Mucosal immunology · 2023Article
- Thermoneutral Housing Enables Studies of Vertical Transmission of Obesogenic Diet-Driven Metabolic Diseases.Nutrients · 2023Article
- Article
- The Influence of Ambient Temperature on Adipose Tissue Homeostasis, Metabolic Diseases and Cancers.Cells · 2023Review
- How murine models of human disease and immunity are influenced by housing temperature and mild thermal stress.Temperature (Austin, Tex.) · 2023Review
- Thermoneutral housing shapes hepatic inflammation and damage in mouse models of non-alcoholic fatty liver disease.Frontiers in immunology · 2023Article
- Mouse models of nonalcoholic steatohepatitis and their application to new drug development.Archives of pharmacal research · 2022Review
- Effect of Different Ambient Temperatures on Reproductive Outcome and Stress Level of Lactating Females in Two Mouse Strains.Animals : an open access journal from MDPI · 2022Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
objectivesObesity and obesity-associated inflammation is central to a variety of end-organ sequelae including atherosclerosis, a leading cause of death worldwide. Although mouse models have provided important insights into the immunopathogenesis of various diseases, modeling atherosclerosis in mice has proven difficult. Specifically, wild-type (WT) mice are resistant to developing atherosclerosis, while commonly used genetically modified mouse models of atherosclerosis are poor mimics of human disease. The lack of a physiologically relevant experimental model of atherosclerosis has hindered the understanding of mechanisms regulating disease development and progression as well as the development of translational therapies. Recent evidence suggests that housing mice within their thermoneutral zone profoundly alters murine physiology, including both metabolic and immune processes. We hypothesized that thermoneutral housing would allow for augmentation of atherosclerosis induction and progression in mice.
methodsApoE
resultsHousing mice at T
conclusionsIn sum, our novel data in WT C57Bl/6 mice suggest that modulation of a single environmental variable, temperature, dramatically alters mouse physiology, metabolism, and inflammation, allowing for an improved mouse model of atherosclerosis. Thus, thermoneutral housing of mice shows promise in yielding a better understanding of the cellular and molecular pathways underlying the pathogenesis of diverse diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.