ArticleMolecular metabolism2016
Depot-specific differences in angiogenic capacity of adipose tissue in differential susceptibility to diet-induced obesity.
Article in Molecular metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 41 citations in OpenAlex.
- Obesity drives depot-specific vascular remodeling in male white adipose tissue.Nature communications · 2025Article
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- White adipocyte dysfunction and obesity-associated pathologies in humans.Nature reviews. Molecular cell biology · 2024Review
- Adipose tissue fibrosis: the unwanted houseguest invited by obesity.The Journal of endocrinology · 2023Review
- Exploring the common gene signatures and pathogeneses of obesity with Alzheimer's diseaseFrontiers in endocrinology · 2022Article
- Immune and Metabolic Biomarkers in a Rodent Model of Spinal Cord Contusion.Global spine journal · 2022Article
- Of mice and men: Pinpointing species differences in adipose tissue biology.Frontiers in cell and developmental biology · 2022Review
- Deletion of adipose triglyceride lipase abolishes blood flow increase after β3-adrenergic stimulation in visceral adipose tissue of mice.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2021Article
- Putative positive role of inflammatory genes in fat deposition supported by altered gene expression in purified human adipocytes and preadipocytes from lean and obese adipose tissues.Journal of translational medicine · 2020Article
- A Straightforward Approach to Engineer Vascularized Adipose Tissue Using Microvascular Fragments.Tissue engineering. Part A · 2020Article
- Pro-inflammatory macrophages coupled with glycolysis remodel adipose vasculature by producing platelet-derived growth factor-B in obesity.Scientific reports · 2020Article
- Deciphering White Adipose Tissue Heterogeneity.Biology · 2019Review
- Acute endurance exercise increases Vegfa mRNA expression in adipose tissue of rats during the early stages of weight gain.Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2018Article
- IGFBP4 Is Required for Adipogenesis and Influences the Distribution of Adipose Depots.Endocrinology · 2017Article
- Increased adipose tissue heme levels and exportation are associated with altered systemic glucose metabolism.Scientific reports · 2017Article
- Spirulina supplement and exercise training affect lipid droplets-related genes expression in visceral adipose tissue.Avicenna journal of phytomedicineArticle
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveAdipose tissue (AT) expansion requires AT remodeling, which depends on AT angiogenesis. Modulation of AT angiogenesis could have therapeutic promise for the treatment of obesity. However, it is unclear how the capacity of angiogenesis in each adipose depot is affected by over-nutrition. Therefore, we investigated the angiogenic capacity (AC) of subcutaneous and visceral fats in lean and obese mice.
methodsWe compared the AC of epididymal fat (EF) and inguinal fat (IF) using an angiogenesis assay in diet-induced obese (DIO) mice and diet-resistant (DR) mice fed a high-fat diet (HFD). Furthermore, we compared the expression levels of genes related to angiogenesis, macrophage recruitment, and inflammation using RT-qPCR in the EF and IF of lean mice fed a low-fat diet (LFD), DIO mice, and DR mice fed a HFD.
resultsDIO mice showed a significant increase in the AC of EF only at 22 weeks of age compared to DR mice. The expression levels of genes related to angiogenesis, macrophage recruitment, and inflammation were significantly higher in the EF of DIO mice than in those of LFD mice and DR mice, while expression levels of genes related to macrophages and their recruitment were higher in the IF of DIO mice than in those of LFD and DR mice. Expression of genes related to angiogenesis (including
conclusionsThese results suggest depot-specific differences in AT angiogenesis and a potential role in the susceptibility to diet-induced obesity.
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