ArticleMolecular metabolism2016
Suppressing hyperinsulinemia prevents obesity but causes rapid onset of diabetes in leptin-deficient
Article in Molecular metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- High Intensity Interval Training can Ameliorate Hypothalamic Appetite Regulation in Male Rats with Type 2 Diabetes: The Role of Leptin.Cellular and molecular neurobiology · 2023Article
- Obesity Duration and Cardiometabolic Disease.Arteriosclerosis, thrombosis, and vascular biology · 2023Review
- Mass cytometry reveals the corneal immune cell changes at single cell level in diabetic mice.Frontiers in endocrinology · 2023Article
- On the causal relationships between hyperinsulinaemia, insulin resistance, obesity and dysglycaemia in type 2 diabetes.Diabetologia · 2021Article
- Placental mTOR complex 1 regulates fetal programming of obesity and insulin resistance in mice.JCI insight · 2021Article
- Hyperinsulinemia in Obesity, Inflammation, and Cancer.Diabetes & metabolism journal · 2021Review
- Tissue-Specific Effects of Leptin on Glucose and Lipid Metabolism.Endocrine reviews · 2021Review
- Effect of Leptin on Chronic Inflammatory Disorders: Insights to Therapeutic Target to Prevent Further Cardiovascular Complication.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Review
- The Transgenerational Transmission of the Paternal Type 2 Diabetes-Induced Subfertility Phenotype.Frontiers in endocrinology · 2021Article
- Review
- Intervertebral disc degeneration in mice with type II diabetes induced by leptin receptor deficiency.BMC musculoskeletal disorders · 2020Article
- Hormesis in Health and Chronic Diseases.Trends in endocrinology and metabolism: TEM · 2019Review
- Article
- In Vivo Rodent Models of Type 2 Diabetes and Their Usefulness for Evaluating Flavonoid Bioactivity.Nutrients · 2019Review
- Liquid Sucrose Consumption Promotes Obesity and Impairs Glucose Tolerance Without Altering Circulating Insulin Levels.Obesity (Silver Spring, Md.) · 2018Article
- The Effects of Plant-Derived Oleanolic Acid on Selected Parameters of Glucose Homeostasis in a Diet-Induced Pre-Diabetic Rat Model.Molecules (Basel, Switzerland) · 2018Article
- Adipocytokines in Rheumatoid Arthritis: The Hidden Link between Inflammation and Cardiometabolic Comorbidities.Journal of immunology research · 2018Review
- Liver-specific reconstitution of CEACAM1 reverses the metabolic abnormalities caused by its global deletion in male mice.Diabetologia · 2017Article
- Insulin action and resistance in obesity and type 2 diabetes.Nature medicine · 2017Review
- Hyperinsulinemia: a Cause of Obesity?Current obesity reports · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectiveHyperinsulinemia is commonly associated with obesity. Mice deficient in the adipose-derived hormone leptin (
methodsLeptin expressing (
resultsWe found that in young
conclusionTaken together, our findings indicate that hyperinsulinemia is required for excess adiposity in
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.