Evidence map›Paper›PMID 27818910›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2016

Biologically Inspired Smart Release System Based on 3D Bioprinted Perfused Scaffold for Vascularized Tissue Regeneration.

Haitao Cui, Wei Zhu, Benjamin Holmes, Lijie Grace Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed.

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  17. Advanced biomaterials for periodontal tissue regeneration.Genesis (New York, N.Y. : 2000) · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Haitao CuiDepartment of Mechanical and Aerospace Engineering Department of Medicine Department of Biomedical Engineering The George Washington University 3590 Science and Engineering Hall 800 22nd Street NW Washington DC 20052 USA.
Wei ZhuDepartment of Mechanical and Aerospace Engineering Department of Medicine Department of Biomedical Engineering The George Washington University 3590 Science and Engineering Hall 800 22nd Street NW Washington DC 20052 USA.
Benjamin HolmesDepartment of Mechanical and Aerospace Engineering Department of Medicine Department of Biomedical Engineering The George Washington University 3590 Science and Engineering Hall 800 22nd Street NW Washington DC 20052 USA.
Lijie Grace ZhangDepartment of Mechanical and Aerospace Engineering Department of Medicine Department of Biomedical Engineering The George Washington University 3590 Science and Engineering Hall 800 22nd Street NW Washington DC 20052 USA.

Funding

A Novel 3D Bioprinted Smart Vascularized Nano TissueDP2EB020549 · NIBIB · GEORGE WASHINGTON UNIVERSITY · PI ZHANG, LIJIE GRACE · 2014 to 2014
$2.3M
NIBIB NIH HHS DP2 EB020549
6 · The paper itself

Abstract

A critical challenge to the development of large-scale artificial tissue grafts for defect reconstruction is vascularization of the tissue construct. As an emerging tissue/organ manufacturing technique, 3D bioprinting offers great precision in controlling the internal architecture of a scaffold with preferable mechanical strength and printing complicated microstructures comparable to native tissue. However, current bioprinting techniques still exhibit difficulty in achieving biomimetic nano resolution and cooperating with bioactive spatiotemporal signals. In this study, a comprehensive design of engineered vascularized bone construct is presented for the first time by integrating biomimetic 3D bioprinted fluid perfused microstructure with biologically inspired smart release nanocoating, which is regarded as an aspiring concept combining engineering, biological, and material science. In this biologically inspired design, angiogenesis and osteogenesis are successively induced through a matrix metalloprotease 2 regulative mechanism by delivering dual growth factors with sequential release in spatiotemporal coordination. Availability of this system is evaluated in dynamic culture condition, which is similar to fluid surrounding in vivo, as an alternative animal model study. Results, particularly from co-cultured dynamically samples demonstrate excellent bioactivity and vascularized bone forming potential of nanocoating modified 3D bioprinted scaffolds for human bone marrow mesenchymal stem cells and human umbilical vein endothelial cells.

Indexed as

3D bioprintingbiologically inspired smart releasenanocoatingspatiotemporal coordinationvascularized bone regeneration

Identifiers

PMID27818910
PMCPMC5074245

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.