Evidence map›Paper›PMID 27818635›Full record

ReviewFrontiers in pharmacology2016

Pharmacogenetics and Predictive Testing of Drug Hypersensitivity Reactions.

Ruwen Böhm, Ingolf Cascorbi

Abstract readReview
In one paragraph

Review in Frontiers in pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Drug hypersensitivity reactions: review of the state of the science for prediction and diagnosis.Toxicological sciences : an official journal of the Society of Toxicology · 2024
    Review
  5. Review
  6. Review
  7. Observational
  8. The Immunogenetics of Cutaneous Drug Reactions.Advances in experimental medicine and biology · 2022
    Article
  9. Article
  10. Article
  11. Genome-wide Study Identifies Association between HLA-BAmerican journal of human genetics · 2020
    Article
  12. Article
  13. Article
  14. In Reply.Deutsches Arzteblatt international · 2018
    Article
  15. Drug Hypersensitivity.Deutsches Arzteblatt international · 2018
    Review
  16. Sulfonamide Drug Allergy.Current allergy and asthma reports · 2018
    Review
  17. Article
  18. Pharmacogenomic Testing in Child and Adolescent Psychiatry: An Evidence-Based Review.Current problems in pediatric and adolescent health care · 2018
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ruwen BöhmInstitute of Experimental and Clinical Pharmacology, University Hospital Schleswig-Holstein Kiel, Germany.
Ingolf CascorbiInstitute of Experimental and Clinical Pharmacology, University Hospital Schleswig-Holstein Kiel, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adverse drug reactions adverse drug reaction (ADR) occur in approximately 17% of patients. Avoiding ADR is thus mandatory from both an ethical and an economic point of view. Whereas, pharmacogenetics changes of the pharmacokinetics may contribute to the explanation of some type A reactions, strong relationships of genetic markers has also been shown for drug hypersensitivity belonging to type B reactions. We present the classifications of ADR, discuss genetic influences and focus on delayed-onset hypersensitivity reactions, i.e., drug-induced liver injury, drug-induced agranulocytosis, and severe cutaneous ADR. A guidance how to read and interpret the contingency table is provided as well as an algorithm whether and how a test for a pharmacogenetic biomarker should be conducted.

Indexed as

adverse drug reactions (ADRs)drug hypersensitivity reactionsdrug-induced agranulocytosis (DIA)drug-induced liver injury (DILI)drug-induced severe cutaneous adverse reactions (SCARs)

Identifiers

PMID27818635
PMCPMC5073094

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.