ArticleFrontiers in behavioral neuroscience2016
Molecular Mechanisms of Stress-Induced Increases in Fear Memory Consolidation within the Amygdala.
Article in Frontiers in behavioral neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03934385 (Optimizing Exposure Therapy With Mental Rehearsal), which is not on this map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Optimizing Exposure Therapy With Mental Rehearsal
Who cites it
21 citing papers in PubMed, 46 citations in OpenAlex.
- Selective Dopamine Transporter Inhibition with CE-123 Promotes Fear Extinction and Alters the Basolateral Amygdala Proteome Following Fear Extinction in Adolescent Male Rats.International journal of molecular sciences · 2026Article
- Effects of Wheat Malt Extract on Molecular and Behavioral Markers in Aged APP/PS1 and Wild-Type Mice.International journal of molecular sciences · 2026Article
- Stress induces distinct social behavior states encoded by the ventral hippocampus.bioRxiv : the preprint server for biology · 2025Article
- MiR-186-5p inhibition restores synaptic transmission and neuronal network activity in a model of chronic stress.Molecular psychiatry · 2025Article
- Targeting Human Glucocorticoid Receptors in Fear Learning: A Multiscale Integrated Approach to Study Functional Connectivity.International journal of molecular sciences · 2024Review
- Elevated corticosterone after fear learning impairs remote auditory memory retrieval and alters brain network connectivity.Learning & memory (Cold Spring Harbor, N.Y.) · 2023Article
- Administration of the glutamate-modulating drug, riluzole, after stress prevents its delayed effects on the amygdala in male rats.PNAS nexus · 2023Article
- Update on neurobiological mechanisms of fear: illuminating the direction of mechanism exploration and treatment development of trauma and fear-related disorders.Frontiers in behavioral neuroscience · 2023Review
- Know thy SEFL: Fear sensitization and its relevance to stressor-related disorders.Neuroscience and biobehavioral reviews · 2022Review
- Morphological changes in the basolateral amygdala and behavioral disruptions associated with social isolation.Behavioural brain research · 2022Article
- The Neurochemical Effects of Prazosin Treatment on Fear Circuitry in a Rat Traumatic Stress Model.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2020Article
- Norepinephrine Induces PTSD-Like Memory ImpairmentsFrontiers in behavioral neuroscience · 2019Article
- Social dominance predicts hippocampal glucocorticoid receptor recruitment and resilience to prenatal adversity.Scientific reports · 2018Article
- Activation of a novel p70 S6 kinase 1-dependent intracellular cascade in the basolateral nucleus of the amygdala is required for the acquisition of extinction memory.Molecular psychiatry · 2018Article
- Midlife stress alters memory and mood-related behaviors in old age: Role of locally activated glucocorticoids.Psychoneuroendocrinology · 2018Article
- Comparative studies of social buffering: A consideration of approaches, terminology, and pitfalls.Neuroscience and biobehavioral reviews · 2018Review
- Catecholamines in Post-traumatic Stress Disorder: A Systematic Review and Meta-Analysis.Frontiers in molecular neuroscience · 2018Article
- Effects of lesions in different nuclei of the amygdala on conditioned taste aversion.Experimental brain research · 2017Article
- Acute gonadotropin-releasing hormone agonist treatment enhances extinction memory in male rats.Psychoneuroendocrinology · 2017Article
- Emotional Modulation of Learning and Memory: Pharmacological Implications.Pharmacological reviews · 2017Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Stress can significantly impact brain function and increase the risk for developing various psychiatric disorders. Many of the brain regions that are implicated in psychiatric disorders and are vulnerable to the effects of stress are also involved in mediating emotional learning. Emotional learning has been a subject of intense investigation for the past 30 years, with the vast majority of studies focusing on the amygdala and its role in associative fear learning. However, the mechanisms by which stress affects the amygdala and amygdala-dependent fear memories remain unclear. Here we review the literature on the enhancing effects of acute and chronic stress on the acquisition and/or consolidation of a fear memory, as measured by auditory Pavlovian fear conditioning, and discuss potential mechanisms by which these changes occur in the amygdala. We hypothesize that stress-mediated activation of glucocorticoid receptors (GR) and norepinephrine release within the amygdala leads to the mobilization of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors to the synapse, which underlies stress-induced increases in fear memory. We discuss the implications of this hypothesis for evaluating the effects of stress on extinction and for developing treatments for anxiety disorders. Understanding how stress-induced changes in glucocorticoid and norepinephrine signaling might converge to affect emotional learning by increasing the trafficking of AMPA receptors and enhancing amygdala excitability is a promising area for future research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.