Evidence map›Paper›PMID 27818614›Full record

ArticleInternational journal for ion mobility spectrometry : official publication of the International Society for Ion Mobility Spectrometry2016

Towards the Analysis of High Molecular Weight Proteins and Protein complexes using TIMS-MS.

Paolo Benigni, Rebecca Marin, Juan Camilo Molano-Arevalo, Alyssa Garabedian, Jeremy J Wolff, Mark E Ridgeway, Melvin A Park, Francisco Fernandez-Lima

Abstract read
In one paragraph

Article in International journal for ion mobility spectrometry : official publication of the International Society for Ion Mobility Spectrometry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Collision-Induced Unfolding of High-Journal of the American Society for Mass Spectrometry · 2025
    Article
  5. Article
  6. Evaluation of a Commercial TIMS-Q-TOF Platform for Native Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Evidence of Cis/Trans-Isomerization at Pro7/Pro16 in the Lasso Peptide Microcin J25.Journal of the American Society for Mass Spectrometry · 2019
    Article
  13. Review
  14. Article
  15. Towards Discovery and Targeted Peptide Biomarker Detection Using nanoESI-TIMS-TOF MS.Journal of the American Society for Mass Spectrometry · 2018
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Paolo BenigniDepartment of Chemistry & Biochemistry, Florida International University, Miami, FL 33199, USA.
Rebecca MarinDepartment of Chemistry & Biochemistry, Florida International University, Miami, FL 33199, USA.
Juan Camilo Molano-ArevaloDepartment of Chemistry & Biochemistry, Florida International University, Miami, FL 33199, USA.
Alyssa GarabedianDepartment of Chemistry & Biochemistry, Florida International University, Miami, FL 33199, USA.
Jeremy J WolffBruker Daltonics, Inc., Billerica, Massachusetts 01821, USA.
Mark E RidgewayBruker Daltonics, Inc., Billerica, Massachusetts 01821, USA.
Melvin A ParkBruker Daltonics, Inc., Billerica, Massachusetts 01821, USA.
Francisco Fernandez-LimaDepartment of Chemistry & Biochemistry, Florida International University, Miami, FL 33199, USA; Biomolecular Science Institute, Florida International University, Miami, FL 33199, USA.

Funding

Mass Spectrometry based molecular imaging of native biological nanodomainsR00GM106414 · NIGMS · FLORIDA INTERNATIONAL UNIVERSITY · PI FERNANDEZ-LIMA, FRANCISCO · 2012 to 2014
$731k
NIGMS NIH HHS R00 GM106414
6 · The paper itself

Abstract

In the present work, we demonstrate the potential and versatility of TIMS for the analysis of proteins, DNA-protein complexes and protein-protein complexes in their native and denatured states. In addition, we show that accurate CCS measurement are possible and in good agreement with previously reported CCS values using other IMS analyzers (<5% difference). The main challenges for the analysis of high mass proteins and protein complexes in the mobility and

Indexed as

IMS-MSIon mobility spectrometry – Mass Spectrometryion—neutral collisional cross sectionsproteinsTIMS

Identifiers

PMID27818614
PMCPMC5091298

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.