Evidence map›Paper›PMID 27818597›Full record

Observational studyWorld journal of gastroenterology2016

Comparison of magnetic resonance spectroscopy, proton density fat fraction and histological analysis in the quantification of liver steatosis in children and adolescents.

Michele Di Martino, Lucia Pacifico, Mario Bezzi, Rossella Di Miscio, Beatrice Sacconi, Claudio Chiesa, Carlo Catalano

Registry-linked trialOpen access · hybridAbstract readComparative StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in World journal of gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02539836 (Study on Dietary Nutrition Intervention Techniques for Children Obesity), which is not on this map. Cited by 56 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 9 pooled it
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02539836 nacompletednot on this map

Study on Dietary Nutrition Intervention Techniques for Children Obesity

TypeinterventionalSponsorChinese Academy of SciencesRan2015 to 2018Enrolled90ConditionsObesity, Intestinal Bacteria Flora Disturbance, Body WeightArmsDietary nutrition based on plant fermentation extract, MRI in quantifying liver fat with MRS
3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 9 syntheses or guidelines pooled it, 98 citations in OpenAlex.

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  6. Change in MRI-PDFF and Histologic Response in Patients With Nonalcoholic Steatohepatitis: A Systematic Review and Meta-Analysis.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Michele Di MartinoMichele Di Martino, Mario Bezzi, Rossella Di Miscio, Beatrice Sacconi, Carlo Catalano, Department of Radiological Sciences, Oncology and Anatomical Pathology, "Sapienza" University of Rome, 00161 Rome, Italy.
Lucia PacificoMichele Di Martino, Mario Bezzi, Rossella Di Miscio, Beatrice Sacconi, Carlo Catalano, Department of Radiological Sciences, Oncology and Anatomical Pathology, "Sapienza" University of Rome, 00161 Rome, Italy.
Mario BezziMichele Di Martino, Mario Bezzi, Rossella Di Miscio, Beatrice Sacconi, Carlo Catalano, Department of Radiological Sciences, Oncology and Anatomical Pathology, "Sapienza" University of Rome, 00161 Rome, Italy.
Rossella Di MiscioMichele Di Martino, Mario Bezzi, Rossella Di Miscio, Beatrice Sacconi, Carlo Catalano, Department of Radiological Sciences, Oncology and Anatomical Pathology, "Sapienza" University of Rome, 00161 Rome, Italy.
Beatrice SacconiMichele Di Martino, Mario Bezzi, Rossella Di Miscio, Beatrice Sacconi, Carlo Catalano, Department of Radiological Sciences, Oncology and Anatomical Pathology, "Sapienza" University of Rome, 00161 Rome, Italy.
Claudio ChiesaMichele Di Martino, Mario Bezzi, Rossella Di Miscio, Beatrice Sacconi, Carlo Catalano, Department of Radiological Sciences, Oncology and Anatomical Pathology, "Sapienza" University of Rome, 00161 Rome, Italy.
Carlo CatalanoMichele Di Martino, Mario Bezzi, Rossella Di Miscio, Beatrice Sacconi, Carlo Catalano, Department of Radiological Sciences, Oncology and Anatomical Pathology, "Sapienza" University of Rome, 00161 Rome, Italy.
Sapienza University of Rome · ITIstituto di Farmacologia Traslazionale · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo establish a threshold value for liver fat content between healthy children and those with non-alcoholic fatty liver disease (NAFLD) by using magnetic resonance imaging (MRI), with liver biopsy serving as a reference standard.

methodsThe study was approved by the local ethics committee, and written informed consent was obtained from all participants and their legal guardians before the study began. Twenty-seven children with NAFLD underwent liver biopsy to assess the presence of nonalcoholic steatohepatitis. The assessment of liver fat fraction was performed using MRI, with a high field magnet and 2D gradient-echo and multiple-echo T1-weighted sequence with low flip angle and single-voxel point-resolved ¹H MR-Spectroscopy (¹H-MRS), corrected for T1 and T2* decays. Receiver operating characteristic curve analysis was used to determine the best cut-off value. Lin coefficient test was used to evaluate the correlation between histology, MRS and MRI-PDFF. A Mann-Whitney

resultsAccording to MRS, the threshold value between healthy children and those with NAFLD is 6%; using MRI-PDFF, a cut-off value of 3.5% is suggested. The Lin analysis revealed a good fit between the histology and MRS as well as MRI-PDFF.

conclusionMRS is an accurate and precise method for detecting NAFLD in children.

Indexed as

Magnetic Resonance SpectroscopyAdolescentBiopsyChildFatty LiverFemaleHumansLiverMagnetic Resonance ImagingMaleMultivariate AnalysisNon-alcoholic Fatty Liver DiseaseObesityProtonsReference ValuesROC CurveProtonsChildrenMagnetic resonance imaging-PDFFMagnetic resonance spectroscopyNon-alcoholic fatty liver diseaseObesity

Identifiers

PMID27818597
PMCPMC5075556
OpenAlexW2536758499

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.