ReviewNature reviews. Nephrology2016
The contribution of branching morphogenesis to kidney development and disease.
Review in Nature reviews. Nephrology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Dissecting Normal and Abnormal Human Kidney Development Using Multiomics.Journal of the American Society of Nephrology : JASN · 2026Review
- Renal dysplasia development and chronic kidney disease.Pediatric research · 2025Review
- MaGNet: A Network-Based Method for Quantitative Analysis of the Mammary Ductal Tree in Developing Female Mice.Journal of mammary gland biology and neoplasia · 2025Article
- Engineering kidney developmental trajectory using culture boundary conditions.Nature communications · 2025Article
- Histone deacetylases and their inhibitors in kidney diseases.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Review
- Early life factors and variation in adult kidney function in the Swedish LifeGene cohort.Scientific reports · 2025Article
- The genetics and pathogenesis of CAKUT.Nature reviews. Nephrology · 2023Review
- Ipsilateral renal dysgenesis or agenesis with tubulocystic anomalies of the mesonephric duct.SA journal of radiology · 2023Article
- Disease mechanisms of monogenic congenital anomalies of the kidney and urinary tract American Journal of Medical Genetics Part C.American journal of medical genetics. Part C, Seminars in medical genetics · 2022Review
- Premature differentiation of nephron progenitor cell and dysregulation of gene pathways critical to kidney development in a model of preterm birth.Scientific reports · 2021Article
- Study of cellular heterogeneity and differential dynamics of autophagy in human embryonic kidney development by single-cell RNA sequencing.Cancer cell international · 2021Article
- Article
- Nascent nephrons during human embryonic development: Spatial distribution and relationship with urinary collecting system.Journal of anatomy · 2021Article
- Single cell RNA sequencing uncovers cellular developmental sequences and novel potential intercellular communications in embryonic kidney.Scientific reports · 2021Article
- Overexpression of Long Non-coding RNA 4933425B07Frontiers in cell and developmental biology · 2021Article
- Article
- Bioprinting: From Tissue and Organ Development toChemical reviews · 2020Review
- Preterm birth and neonatal acute kidney injury: implications on adolescent and adult outcomes.Journal of perinatology : official journal of the California Perinatal Association · 2020Review
- Extracellular matrix dynamics in tubulogenesis.Cellular signalling · 2020Review
- The bronchial tree of the human embryo: an analysis of variations in the bronchial segments.Journal of anatomy · 2020Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mammalian kidney develops from a simple epithelial bud to an arborized network of tubules, which are fated to form the ureter, renal pelvis and collecting ducts. This process of ductal elaboration is achieved through an ancient developmental mechanism known as branching morphogenesis that is widely employed in glandular organs, the vasculature and lungs. It breaks up large solid tissues facilitating secretion, excretion and gas exchange, depending on the tissue. In the kidney, growth of the ureteric bud is driven by interactions between progenitor cells in the tips of the epithelial tree and their mesenchymal 'caps'. The cells of the cap mesenchyme give rise to nephrons; therefore, the interaction between these two cell populations is likely to be a critical driver of nephron number, which is determined during gestation. These cellular interactions are potentially affected by genetic mutations (congenital kidney diseases) and by changes in the fetal environment. Understanding the aetiology of congenital and acquired kidney diseases therefore requires a full appreciation of the processes involved in establishing the cellular architecture of the kidney and of the factors that affect the commitment of progenitor cells to form nephrons.
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