Observational studyChest2017
Clinical Features of Smokers With Radiological Emphysema But Without Airway Limitation.
Observational study in Chest, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03263130 (Site and Mechanism), which is not on this map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Site and Mechanism(s) of Expiratory Airflow Limitation in COPD, Emphysema and Asthma-COPD Overlap
Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- Is Type and Grade of Emphysema Important for Bone Mineral Density and Aortic Calcifications?Journal of clinical medicine · 2024Article
- The Role of Pulmonary Function Testing in the Diagnosis and Management of COPD.Respiratory care · 2023Review
- Emphysema Detection in the Course of Lung Cancer Screening: Optimizing a Rare Opportunity to Impact Population Health.Annals of the American Thoracic Society · 2023Article
- Prevalence of reduced lung diffusing capacity and CT scan findings in smokers without airflow limitation: a population-based study.BMJ open respiratory research · 2023Article
- Definition and Nomenclature of Chronic Obstructive Pulmonary Disease: Time for Its Revision.American journal of respiratory and critical care medicine · 2022Article
- Chest CT scan for the screening of air anomalies at risk of pulmonary barotrauma for the initial medical assessment of fitness to dive in a military population.Frontiers in physiology · 2022Article
- Phenotypic characterisation of early COPD: a prospective case-control study.ERJ open research · 2020Article
- Value of metalloproteinases in predicting COPD in heavy urban smokers.Respiratory research · 2020Observational
- Risk factors associated with the detection of pulmonary emphysema in older asymptomatic respiratory subjects.BMC pulmonary medicine · 2020Observational
- Chronic obstructive pulmonary disease at the beginning of the XXI Century.Journal of thoracic disease · 2019Article
- COPD beyond proximal bronchial obstruction: phenotyping and related tools at the bedside.European respiratory review : an official journal of the European Respiratory Society · 2019Review
- Cardiopulmonary and Muscular Interactions: Potential Implications for Exercise (In)tolerance in Symptomatic Smokers Without Chronic Obstructive Pulmonary Disease.Frontiers in physiology · 2019Review
- Are Systemic Manifestations Ascribable to COPD in Smokers? A Structural Equation Modeling Approach.Scientific reports · 2018Article
- Emphysema and bronchiectasis in COPD patients with previous pulmonary tuberculosis: computed tomography features and clinical implications.International journal of chronic obstructive pulmonary disease · 2018Article
- COPD: time to improve its taxonomy?ERJ open research · 2018Article
- Natural history of COPD: gaps and opportunities.ERJ open research · 2017Article
- Increased circulating βScientific reports · 2017Article
- Usefulness of the desaturation-distance ratio from the six-minute walk test for patients with COPD.International journal of chronic obstructive pulmonary disease · 2017Article
- Evaluation of symptomatic patients without airflow obstruction: back to the future.Journal of thoracic disease · 2016Article
- Factors related to instrumental activities of daily living in persons with chronic thromboembolic pulmonary hypertension.Chronic respiratory diseaseObservational
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe clinical characteristics of patients with emphysema but without airway limitations remain unknown. The goal of this study was to compare the clinical features of current and former smokers without airflow limitation who have radiologic emphysema on chest CT scans vs a control group of current and ex-smokers without emphysema.
methodsSubjects enrolled had anthropometric characteristics recorded, provided a medical history, and underwent low-dose chest CT scanning. The following parameters were also evaluated: pulmonary function tests including diffusion capacity for carbon monoxide (Dlco), the modified Medical Research Council dyspnea score, COPD assessment test (CAT), and 6-min walk test (6MWT). A comparison was conducted between those with and without CT-confirmed emphysema.
resultsOf the 203 subjects, 154 had emphysema, and 49 did not. Adjusted group comparisons revealed that a higher proportion of patients with emphysema according to low-dose chest CT scanning had an abnormal Dlco value (< 80%) (46% vs 19%; P = .02), a decrease in percentage of oxygen saturation > 4% during the 6MWT (8.5% vs 0; P = .04), and an altered quality of life (CAT score ≥ 10) (32% vs 14%; P = .01). A detailed analysis of the CAT questionnaire items revealed that more patients with emphysema had a score ≥ 1 in the "chest tightness" (P = .05) and "limitation when doing activities at home" (P < .01) items compared with those with no emphysema. They also experienced significantly more exacerbations in the previous year (0.19 vs 0.04; P = .02).
conclusionsA significant proportion of smokers with emphysema according to low-dose chest CT scanning but without airway limitation had alterations in their quality of life, number of exacerbations, Dlco values, and oxygen saturation during the 6MWT test.
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